Herpes Simplex Virus-Induced Epithelial Damage and Susceptibility to Human Immunodeficiency Virus Type 1 Infection in Human Cervical Organ Culture 英文参考文献.docVIP

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Herpes Simplex Virus-Induced Epithelial Damage and Susceptibility to Human Immunodeficiency Virus Type 1 Infection in Human Cervical Organ Culture 英文参考文献.doc

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Herpes Simplex Virus-Induced Epithelial Damage and Susceptibility to Human Immunodeficiency Virus Type 1 Infection in Human Cervical Organ Culture 英文参考文献

HerpesSimplexVirus-InducedEpithelialDamageand SusceptibilitytoHumanImmunodeficiencyVirusType1 InfectioninHumanCervicalOrganCulture JulieE.Horbul1¤a,StephenC.Schmechel2,BarrieR.L.Miller1¤b,StephenA.Rice1,PeterJ.Southern1* 1Department of Microbiology, University of Minnesota, Minneapolis, Minnesota, United States of America, 2Department of Laboratory Medicine and Pathology, UniversityofMinnesota,Minneapolis,Minnesota,UnitedStatesofAmerica Abstract Normal human premenopausal cervical tissue has been used to derive primary cell populations and to establish ex vivo organculturesystemstostudyinfectionswithherpessimplexvirus(HSV-1orHSV-2)andhumanimmunodeficiencyvirus type 1 (HIV-1). Infection with either HSV-1 or HSV-2 rapidly induced multinuclear giant cell formation and widespread damageinmucosalepithelialcells.SubsequentexposureofthedamagedmucosalsurfacestoHIV-1revealedfrequentco- localizationofHSVandHIV-1antigens.Theshort-termorganculturesystemprovidesdirectexperimentalsupportforthe epidemiological findings that pre-existing sexually transmitted infections, including primary and recurrent herpes virus infectionsatmucosalsurfaces,representmajorriskfactorsforacquisitionofprimaryHIV-1infection.Epithelialdamagein combinationwithpre-existinginflammation,asdescribedhereforovertlynormalhumanpremenopausalcervix,createsa highly susceptible environment for the initiation andestablishment of primary HIV-1infection in the sub-mucosa of the cervicaltransformationzone. Citation: Horbul JE, Schmechel SC, Miller BRL, Rice SA, Southern PJ (2011) Herpes Simplex Virus-Induced Epithelial Damage and Susceptibility to Human ImmunodeficiencyVirusType1InfectioninHumanCervicalOrganCulture.PLoSONE6(7):e22638.doi:10.1371/journal.pone.0022638 Editor:HermanTse,TheUniversityofHongKong,HongKong ReceivedNovember2,2010;AcceptedJuly3,2011;PublishedJuly27,2011 Copyright: ? 2011 Horbul et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which p