Metabolic Effects of Fluoxetine in Adults with Type 2 Diabetes Mellitus A Meta-Analysis of Randomized Placebo-Controlled Trials 英文参考文献.docVIP

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Metabolic Effects of Fluoxetine in Adults with Type 2 Diabetes Mellitus A Meta-Analysis of Randomized Placebo-Controlled Trials 英文参考文献.doc

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Metabolic Effects of Fluoxetine in Adults with Type 2 Diabetes Mellitus A Meta-Analysis of Randomized Placebo-Controlled Trials 英文参考文献

MetabolicEffectsofFluoxetineinAdultswithType2 DiabetesMellitus:AMeta-AnalysisofRandomized Placebo-ControlledTrials ZiYe1.,LiliChen1.,ZhenYang2*,QinLi1,YingHuang1,MinHe1,ShuoZhang1,ZhaoyunZhang1, XuanchunWang1,WeiweiZhao1,JiHu3,ChaoLiu4,ShenQu2,RenmingHu1* 1InstituteofEndocrinologyandDiabetology,HuashanHospital,ShanghaiMedicalCollege,FudanUniversity,Shanghai,China,2DepartmentofEndocrinology,Shanghai TenthPeople’sHospital,SchoolofMedicine,TongjiUniversity,Shanghai,China,3DepartmentofEndocrinology,TheSecondAffiliatedHospitalofSoochowUniversity, Suzhou, China, 4Department of Endocrinology, Jiangsu Province Hospital on Integration of Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing,China Abstract Background:Theprevalenceofobesityanddiabetesisincreasingdramaticallythroughouttheworld.Studieshaveshown thatexcessadiposityisacriticalpredictorofnewonsetT2DM.Thismeta-analysisisaimedtoassessthemetaboliceffectsof fluoxetineinT2DM. Methods and Findings: Electronic search was conducted in the database Medline, PubMed, EMBASE, and the Cochrane library,frominceptionthroughtoMarch2011.Asystematicreviewofthestudiesonthemetaboliceffectsoffluoxetinein T2DMwasperformed.Theweightedmeandifference(WMD)andits95%CIwerecalculatedfromtherawdataextracted fromtheoriginalliterature. ThesoftwareReviewManager(version4.3.1)andStata(version11.0)wereappliedformeta- analysis. Five randomized, placebo-controlled trials were included in the meta-analysis. According to WMD calculation, fluoxetinetherapyledto4.27Kgofweightloss(95%CI2.58–5.97,P,0.00001),1.41mmol/Loffastingplasmaglucose(FPG) decrement (95%CI 0.19–2.64, P=0.02) and 0.54mmol/L of triglyceride (TG) reduction (95%CI 0.35–0.73, P,0.000 01) comparedwithplacebo.Moreover,fluoxetinetherapyproduced0.78%ofHbA1cdecrement(95%CI20.23–1.78).However, thiseffectwasnotstatisticallysignificant(P =0.13). Conclusions:ShortperiodoffluoxetinetherapycanleadtoweightlossaswellasreductionofFPG,HbA1candTGinT2DM. Citation:YeZ,ChenL,YangZ,L