Metabolite Profiling Identifies Candidate Markers Reflecting the Clinical Adaptations Associated with Roux-en-Y Gastric Bypass Surgery 英文参考文献.docVIP

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Metabolite Profiling Identifies Candidate Markers Reflecting the Clinical Adaptations Associated with Roux-en-Y Gastric Bypass Surgery 英文参考文献.doc

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Metabolite Profiling Identifies Candidate Markers Reflecting the Clinical Adaptations Associated with Roux-en-Y Gastric Bypass Surgery 英文参考文献

MetaboliteProfilingIdentifiesCandidateMarkers ReflectingtheClinicalAdaptationsAssociatedwith Roux-en-YGastricBypassSurgery DavidM.Mutch1,2¤*,JensC.Fuhrmann3,DietrichRein4*,JanC.Wiemer3,Jean-LucBouillot5 ,Christine Poitou1,2,6,KarineCle′ment1,2,6 1NutriomiqueU872team7,InstitutNationaldelaSante′etdelaRechercheMe′dicale,Paris,France,2CentredeRecherchedesCordeliers,Universite′PierreetMarieCurie – Paris 6, Paris, France, 3metanomics GmbH, Berlin, Germany, 4metanomics Health GmbH, Berlin, Germany, 5Ho?tel-Dieu Hospital Surgery Department, Assistance Publique-Ho?pitauxdeParis,Paris,France,6Pitie′-Salpe?trie`reHospitalNutritionandEndocrinologyDepartment,AssistancePublique-Ho?pitauxdeParis,Paris,France Abstract Background: Roux-en-Y gastric bypass (RYGB) surgery is associated with weight loss, improved insulin sensitivity and glucosehomeostasis,andareductioninco-morbiditiessuchasdiabetesandcoronaryheartdisease.Togeneratefurther insightintothenumerousmetabolicadaptationsassociatedwithRYGBsurgery,weprofiledserummetabolitesbeforeand aftergastricbypasssurgeryandintegratedmetabolitechangeswithclinicaldata. MethodologyandPrincipalFindings:Serummetabolitesweredetectedbygasandliquidchromatography-coupledmass spectrometrybefore,and3and6monthsafterRYGBinmorbidlyobesefemalesubjects(n=14;BMI=46.261.7).Subjects showed decreases in weight-related parameters andimprovements in insulin sensitivity post surgery. The abundance of 48%(83of172)ofthemeasuredmetaboliteschangedsignificantlywithinthefirst3monthspostRYGB(p,0.05),including sphingosines, unsaturated fatty acids, and branched chain amino acids. Dividing subjects into obese (n=9) and obese/ diabetic(n=5)groupsidentified8metabolitesthatdifferedconsistentlyatalltimepointsandwhoseserumlevelschanged following RYGB: asparagine, lysophosphatidylcholine (C18:2), nervonic (C24:1) acid, p-Cresol sulfate, lactate, lycopene, glucose,andmannose.Changesintheaforementionedmetaboliteswereintegratedwithclinicaldataforbodymassindex (BMI)andestimatesfo