Metabolomics Reveals Metabolic Biomarkers of Crohns Disease 英文参考文献.docVIP

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Metabolomics Reveals Metabolic Biomarkers of Crohns Disease 英文参考文献.doc

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Metabolomics Reveals Metabolic Biomarkers of Crohns Disease 英文参考文献

MetabolomicsRevealsMetabolicBiomarkersofCrohn’s Disease JanetJansson1,2.,BenWilling2.,MariannaLucio3.,AgesFekete3,JohanDicksved2,JonasHalfvarson4, CurtTysk4,PhilippeSchmitt-Kopplin3* 1EcologyDepartment,DivisionofEarthSciences,LawrenceBerkeleyNationalLaboratory,Berkeley,California,UnitedStatesofAmerica,2DepartmentofMicrobiology, SwedishUniversityofAgriculturalSciences,Uppsala,Sweden,3Helmholtz-ZentrumMuenchen-GermanResearchCenterforEnvironmentalHealth,InstituteforEcological Chemistry,Neuherberg,Germany,4DepartmentofMedicine,DivisionofGastroenterology,O¨rebroUniversityHospitalandSchoolofHealthandMedicalSciences,O¨rebro University,O¨rebro,Sweden Abstract ThecausesandetiologyofCrohn’s disease(CD) arecurrentlyunknownalthough bothhostgenetics andenvironmental factorsplayarole.Hereweusednon-targetedmetabolicprofilingtodeterminethecontributionofmetabolitesproduced bythegutmicrobiotatowardsdiseasestatusofthehost.IonCyclotronResonanceFourierTransformMassSpectrometry (ICR-FT/MS)wasusedtodiscernthemassesofthousandsofmetabolitesinfecalsamplescollectedfrom17identicaltwin pairs,includinghealthyindividualsandthosewithCD.Pathwayswithdifferentiatingmetabolitesincludedthoseinvolvedin the metabolism and or synthesis of amino acids, fatty acids, bile acids and arachidonic acid. Several metabolites were positivelyornegativelycorrelatedtothediseasephenotypeandtospecificmicrobespreviouslycharacterizedinthesame samples. Our data reveal novel differentiating metabolites for CD that may provide diagnostic biomarkers and/or monitoringtoolsaswellasinsightintopotentialtargetsfordiseasetherapyandprevention. Citation:JanssonJ,WillingB,LucioM,FeketeA,DicksvedJ,etal.(2009)MetabolomicsRevealsMetabolicBiomarkersofCrohn’sDisease.PLoSONE4(7):e6386. doi:10.1371/journal.pone.0006386 Editor:StefanBereswill,Charite′-Universita¨tsmedizin Berlin,Germany ReceivedJune11,2009;AcceptedJune25,2009;PublishedJuly28,2009 Thisisanopen-accessarticledistributedunderthetermsoftheCreativeCommonsPublicDomaindeclara