Methods for Structuring Scientific Knowledge from Many Areas Related to Aging Research 英文参考文献.docVIP

MethodsforStructuringScientificKnowledgefromMany AreasRelatedtoAgingResearch AlexZhavoronkov1,2*,CharlesR.Cantor3,4 1TheRussianStateMedicalUniversity,Moscow,RussianFederation,2TheBiogerontologyResearchFoundation,Reading,UnitedKingdom,3DepartmentofBiomedical Engineering, Boston University, Boston, Massachusetts, United States of America, 4Department of Physiology and Biophysics, University of California Irvine, Irvine, California,UnitedStatesofAmerica Abstract Agingandage-relateddiseaserepresentsasubstantialquantityofcurrentnatural,socialandbehavioralscienceresearch efforts.Presently,nocentralizedsystemexistsfortrackingagingresearchprojectsacrossnumerousresearchdisciplines.The multidisciplinarynatureofthisresearchcomplicatestheunderstandingofunderlyingprojectcategories,theestablishment of project relations, and the development of a unified project classification scheme. We have developed a highly visual database, the International Aging Research Portfolio (IARP), available at AgingP to address this issue. The database integrates information on research grants, peer-reviewed publications, and issued patent applications from multiplesources.Additionally,thedatabaseusesflexibleprojectclassificationmechanismsandtoolsforanalyzingproject associationsandtrends.Thissystemenablesscientiststosearchthecentralizedprojectdatabase,toclassifyandcategorize aging projects, and to analyze the funding aspects across multiple research disciplines. The IARP is designed to provide improved allocation and prioritization of scarce research funding, to reduce project overlap and improve scientific collaborationtherebyacceleratingscientificandmedicalprogressinarapidlygrowingareaofresearch.Grantapplications oftenprecedepublicationsandsomegrantsdonotresultinpublications,thus,thissystemprovidesutilitytoinvestigatean earlier and broader view on research activity in many research disciplines. This project is a first attempt to provide a centralized database system for research grants and to catego