Microarray Analysis Reveals Distinct Gene Expression Profiles Among Different Tumor Histology, Stage and Disease Outcomes in Endometrial Adenocarcinoma 英文参考文献.docVIP

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Microarray Analysis Reveals Distinct Gene Expression Profiles Among Different Tumor Histology, Stage and Disease Outcomes in Endometrial Adenocarcinoma 英文参考文献.doc

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Microarray Analysis Reveals Distinct Gene Expression Profiles Among Different Tumor Histology, Stage and Disease Outcomes in Endometrial Adenocarcinoma 英文参考文献

MicroarrayAnalysisRevealsDistinctGeneExpression ProfilesAmongDifferentTumorHistology,Stageand DiseaseOutcomesinEndometrialAdenocarcinoma PauletteMhawech-Fauceglia1*,DanWang2,JoshuaKesterson3,KimberlyClark4,LaketaMonhollen1, KunleOdunsi3,ShashikantLele3,SongLiu2* 1Department of Pathology, Roswell Park Cancer Institute, Buffalo, New York, United States of America, 2Department of Biostatistics, Roswell Park Cancer Institute, Buffalo,NewYork,UnitedStatesofAmerica,3DepartmentofGynecology-OncologySurgery,RoswellParkCancerInstitute,Buffalo,NewYork,UnitedStatesofAmerica, 4DepartmentofCancerGenetics,RoswellParkCancerInstitute,Buffalo,NewYork,UnitedStatesofAmerica Abstract Background:Endometrialcanceristhemostcommongynecologicmalignancyindevelopedcountriesandlittleisknown about the underlying mechanism of stage and disease outcomes. The goal of this study was to identify differentially expressed genes (DEG) between late vs. early stage endometrioid adenocarcinoma (EAC) and uterine serous carcinoma (USC),aswellasbetweendiseaseoutcomesineachofthetwohistologicalsubtypes. Methodology/PrincipalFinding:Geneexpressionprofilesof20cancersampleswereanalyzed(EAC=10,USC=10)using thehumangenomewideilluminabeadmicroarrays.TherewaslittleoverlapintheDEGsetsbetweenlatevs.earlystagesin EAC and USC, and there was an insignificant overlap in DEG sets between good and poor prognosis in EAC and USC. Remarkably,therewasnooverlapbetweenthestage-derivedDEGsandtheprognosis-derivedDEGsforeachofthetwo histological subtypes. Further functional annotation of differentially expressed genes showed that the composition of enrichedfunctiontermsweredifferentamongdifferentDEGsets.Geneexpressiondifferencesforselectedgenesofvarious stagesandoutcomeswereconfirmedbyqRT-PCRwithahighvalidationrate. Conclusion:Thisdata,althoughpreliminary,suggeststhattheremightbeinvolvementofdistinctgroupsofgenesintumor progression (latevs. earlystage) ineach oftheEAC andUSC. It also suggests thatthese genesaredifferent fromthose i