Mortality among Patients with Cleared Hepatitis C Virus Infection Compared to the General Population A Danish Nationwide Cohort Study 英文参考文献.docVIP

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Mortality among Patients with Cleared Hepatitis C Virus Infection Compared to the General Population A Danish Nationwide Cohort Study 英文参考文献.doc

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Mortality among Patients with Cleared Hepatitis C Virus Infection Compared to the General Population A Danish Nationwide Cohort Study 英文参考文献

MortalityamongPatientswithClearedHepatitisCVirus InfectionComparedtotheGeneralPopulation:ADanish NationwideCohortStudy LarsHaukaliOmland1*,PeerBrehmChristensen2,HenrikKrarup3,PeterJepsen4,5,NinaWeis6 ,Henrik ToftS?rensen4,7,NielsObel1,onbehalfoftheDANVIRCohortStudy 1Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark, 2Department of Infectious Diseases, Odense University Hospital, Odense, Denmark, 3Department of Clinical Biochemistry, Aarhus University Hospital, Aalborg Hospital, Aalborg, Denmark, 4Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark, 5Department of Medicine V (Hepatology and Gastroenterology), Aarhus University Hospital, Aarhus, Denmark, 6Department of Infectious Diseases, Copenhagen University Hospital, Hvidovre Hospital, Copenhagen, Denmark, 7Department of Epidemiology, Boston UniversitySchoolofPublicHealth,Boston,Massachusetts,UnitedStatesofAmerica Abstract Background:TheincreasedmortalityinHCV-infectedindividualspartlystemsfromviraldamagetotheliverandpartlyfrom risk-taking behaviours. We examined mortality in patients who cleared their HCV-infection, comparing it to that of the generalpopulation.Wealsoaddressedthequestionwhetherprognosisdifferedaccordingtoage,substanceabuse(alcohol abuseandinjectiondruguse)andcomorbidity. Methodology/PrincipalFindings:PatientswithclearedHCV-infectionwerecategorizedintooneof8groupsaccordingto age (20–39 years or 40–69 years) and patient characteristics (no substance abuse/no comorbidity; substance abuse/no comorbidity; no substance abuse/comorbidity; and substance abuse/comorbidity). For each patient, 4 age- and gender- matchedindividualswithoutsubstanceabuseorcomorbiditywereselectedfromthegeneralpopulation,comprisingatotal of8comparisoncohorts.Weanalyzed10-yearsurvivalandusedstratifiedCoxRegressionanalysistocomputemortalityrate ratios (MRRs), comparing mortality between the 8 patient groups and the comparison cohorts, adjusting fo