Multisensory Integration and Attention in Autism Spectrum Disorder Evidence from Event-Related Potentials 英文参考文献.docVIP

MultisensoryIntegrationandAttentioninAutism SpectrumDisorder:EvidencefromEvent-Related Potentials MauriceJ.C.M.Magne′e1,2*,BeatricedeGelder2,3,HermanvanEngeland1,ChantalKemner1,4 1DepartmentofChildandAdolescentPsychiatry,RudolfMagnusInstituteofNeuroscience,UniversityMedicalCenterUtrecht,Utrecht,TheNetherlands,2Laboratoryof CognitiveandAffectiveNeuroscience,TilburgUniversity,Tilburg,TheNetherlands,3MartinosCenterforBiomedicalImaging,MassachusettsGeneralHospitalandHarvard MedicalSchool,Charlestown,Massachusetts,UnitedStatesofAmerica,4DepartmentofDevelopmentalPsychology,UtrechtUniversity,Utrecht,TheNetherlands Abstract Successfulintegrationofvarioussimultaneouslyperceivedperceptualsignalsiscrucialforsocialbehavior.Recentfindings indicate that this multisensory integration (MSI) can be modulated by attention. Theories of Autism Spectrum Disorders (ASDs)suggestthatMSIisaffectedinthispopulationwhileitremainsuncleartowhatextentthisisrelatedtoimpairments in attentional capacity. In the present study Event-related potentials (ERPs) following emotionally congruent and incongruent face-voice pairs were measured in 23 high-functioning, adult ASD individuals and 24 age- and IQ-matched controls.MSIwasstudiedwhiletheattentionoftheparticipantswasmanipulated.ERPsweremeasuredattypicalauditory andvisualprocessingpeaks,namely,P2andN170.WhilecontrolsshowedMSIduringdividedattentionandeasyselective attention tasks, individuals with ASD showed MSI during easy selective attention tasks only. It was concluded that individuals with ASD are able to process multisensory emotional stimuli, but this is differently modulated by attention mechanisms in these participants, especially those associated with divided attention. This atypical interaction between attentionandMSIisalsorelevanttotreatmentstrategies,withtrainingofmultisensoryattentionalcontrolpossiblybeing morebeneficialthanconventionalsensoryintegrationtherapy. Citation:Magne′eMJCM,deGelderB,vanEngelandH,KemnerC(2011)MultisensoryIntegrati