Numerical Optimization of a Microfluidic Assisted Microarray for the Detection of Biochemical Interactions 英文参考文献.docVIP

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Numerical Optimization of a Microfluidic Assisted Microarray for the Detection of Biochemical Interactions 英文参考文献.doc

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Numerical Optimization of a Microfluidic Assisted Microarray for the Detection of Biochemical Interactions 英文参考文献

Sensors 2011, 11, 9658-9666; doi:10.3390/s111009658 OPEN ACCESS sensors ISSN 1424-8220 /journal/sensors Article Numerical Optimization of a Microfluidic Assisted Microarray for the Detection of Biochemical Interactions Emanuele Orabona 1,2,*, Ilaria Rea 1, Ivo Rendina 1 and Luca De Stefano 1 1 Institute for Microelectronics and Microsystems, Naples Unit, National Research Council, Via P. Castellino 111, 80131 Napoli, Italy; E-Mails: ilaria.rea@r.it (I.R.); ivo.rendina@r.it (I.R.); luca.destefano@r.it (L.D.S.) 2 Department of Physics, University of Naples “Federico II”, Via Cinthia, 80128 Napoli, Italy * Author to whom correspondence should be addressed; E-Mail: emanuele.orabona@r.it; Tel.: +39-08-1613-2594; Fax: +39-08-1613-2698. Received: 16 September 2011; in revised form: 7 October 2011 / Accepted: 9 October 2011 / Published: 12 October 2011 Abstract: Finite element method analysis was applied to the characterization of the biomolecular interactions taking place in a microfluidic assisted microarray. Numerical simulations have been used for the optimization of geometrical and physical parameters of the sensing device. Different configurations have been analyzed and general considerations have been derived. We have shown that a parallel disposition of the sensing area allows the homogeneous formation of the target molecular complex in all the active zones of the microarray. Stationary and time dependent results have also been obtained. Keywords: microfluidics; biosensing; reaction kinetics 1. Introduction In the past two decades microfluidics has emerged as a powerful tool for biosensing [1] and biophotonics [2]. Micro?uidic devices require small reagent volumes, short reaction times and allow high throughput due to their parallel mode of operation. Microfluidics represent a fundamental tool to integrate almost all the functionality of a laboratory onto a single chip, i.e., a lab-on-a-chip. Microfluid