Occurrence and Treatment of Bone Atrophic Non-Unions Investigated by an Integrative Approach 英文参考文献.docVIP

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Occurrence and Treatment of Bone Atrophic Non-Unions Investigated by an Integrative Approach 英文参考文献.doc

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Occurrence and Treatment of Bone Atrophic Non-Unions Investigated by an Integrative Approach 英文参考文献

OccurrenceandTreatmentofBoneAtrophicNon-Unions InvestigatedbyanIntegrativeApproach LiesbetGeris1,2,3.*,AnitaA.C.Reed4,5.,JosVanderSloten1,A.HamishR.W.Simpson6,HansVan Oosterwyck1,2 1DivisionofBiomechanicsandEngineeringDesign,DepartmentofMechanicalEngineering,KatholiekeUniversiteitLeuven,Leuven,Belgium,2Prometheus,Divisionof SkeletalTissueEngineering,KatholiekeUniversiteitLeuven,Leuven,Belgium,3BiomechanicsResearchUnit,UniversityofLie`ge,Lie`ge,Belgium,4NuffieldDepartmentof Orthopaedic Surgery, University of Oxford, Oxford, United Kingdom, 5Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom, 6DepartmentofTraumaOrthopaedics,EdinburghUniversity,Edinburgh,UnitedKingdom Abstract Recently developed atrophic non-union models are a good representation of the clinical situation in which many non- unionsdevelop.Basedonpreviousexperimentalstudieswiththeseatrophicnon-unionmodels,itwashypothesizedthatin ordertoobtainsuccessfulfracturehealing,bloodvessels,growthfactors,and(proliferative)precursorcellsallneedtobe presentinthecallusatthesametime.Thisstudyusesacombinedinvivo-insilicoapproachtoinvestigatethesedifferent aspects(vasculature,growthfactors,cellproliferation).Themathematicalmodel,initiallydevelopedforthestudyofnormal fracturehealing,isabletocaptureessentialaspectsoftheinvivoatrophicnon-unionmodeldespiteanumberofdeviations thataremainlyduetosimplificationsintheinsilicomodel.Themathematicalmodelissubsequentlyusedtotestpossible treatmentstrategiesforatrophicnon-unions(i.e.celltransplantatpost-osteotomy,week3).Preliminaryinvivoexperiments corroboratethenumericalpredictions.Finally,themathematicalmodelisappliedtoexplainexperimentalobservationsand identifypotentiallycrucialstepsinthetreatmentsandcantherebybeusedtooptimizeexperimentalandclinicalstudiesin thisarea.Thisstudydemonstratesthepotentialofthecombinedinsilico-invivoapproachanditsclinicalimplicationsfor theearlytreatmentofpatientswithproblematicfractures. Citation:GerisL,ReedAAC,Vande