On the use of animal models in the analysis of selection experiments 英文参考文献.docVIP

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On the use of animal models in the analysis of selection experiments 英文参考文献.doc

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On the use of animal models in the analysis of selection experiments 英文参考文献

1 Louis Ollivier Station de génétique quantitative et appliquée, Institut national de la recherche agronomique, 78352 Jouy-en-Josas cedex, France (Received 25 May 1998; accepted 28 January 1999) Abstract - The use of an animal model in the analysis of selection experiments offers the theoretical advantage of accounting for changes occurring in the genetic parame- ters in the course of the experiments. Explicit estimators of realized heritability (h2) are derived in this paper for balanced one-generation selection designs. Expressions are given for the expectations and variances of the estimators in relation to the true heritability and for the sensitivity of the estimators to the prior value of heritability. Sensitivity is generally high, except for high values of the true heritability and/or extremely large family sizes. The uncertainty on heritability may, however, be taken into account in a context of Bayesian inference, which allows a simultaneous esti- mation of the initial heritability and of the response. On the other hand, animal model estimators, being dependent on the genetic model assumed, may not provide adequate measures of the actual responses. They also tend to overestimate the ac- curacy of genetic trend evaluations, since genetic drift is not properly accounted for. Animal models, however, provide a way of evaluating the effects of selection and lim- ited population size in long-term selection experiments, and thus permit a check on the validity of the underlying infinitesimal additive genetic model. Some examples based on published results of long-term selection experiments on mice are discussed. copy; Inra/Elsevier, Paris genetic evaluation / selection experiment / animal heritability model BLUP / realized Résumé - Utilisation du sélection. L’application du modèle animal à l’analyse des expériences de sélection permet en théorie une prise en compte de l’évolution des paramètres génétiques 1 a contribution presented by the auth