Optic Flow Stimuli in and Near the Visual Field Centre A Group fMRI Study of Motion Sensitive Regions 英文参考文献.docVIP

OpticFlowStimuliinandNeartheVisualFieldCentre:A GroupfMRIStudyofMotionSensitiveRegions SabineOhlendorf1,3,6,AndreasSprenger2,OliverSpeck3,4,SvenHaller5,HubertKimmig2,7* 1Neurologische Klinik, Universita¨tsklinikum, Freiburg, Germany, 2Klinik fu¨r Neurologie, Universita¨tsklinikum Schleswig Holstein, Campus Lu¨beck, Lu¨beck, Germany, 3AbteilungRo¨ntgendiagnostik,MedizinPhysik,Universita¨tsklinikum,Freiburg,Germany,4AbteilungBiomedizinischeMagnetresonanz,Institutfu¨rExperimentellePhysik, Universita¨tMagdeburg,Magdeburg,Germany,5Abteilungfu¨rNeuroradiologie,Universita¨tsspital,Basel,Switzerland,6Fakulta¨tfu¨rBiologie,Universita¨tFreiburg,Freiburg, Germany,7Schwarzwald-Baar-Klinikum,AcademicTeachingHospitalUniversita¨t Freiburg,Villingen-Schwenningen,Germany Abstract Motionstimuliinonevisualhemifieldactivatehumanprimaryvisualareasofthecontralateralside,butsuppressactivityof the corresponding ipsilateral regions. While hemifield motion is rare in everyday life, motion in both hemifields occurs regularlywheneverwemove.Consequently,duringmotionprimaryvisualregionsshouldsimultaneouslyreceiveexcitatory and inhibitory inputs. A comparison of primary and higher visual cortex activations induced by bilateral and unilateral motionstimuliismissinguptonow.ManymotionstudiesfocusedontheMT+complexintheparieto-occipito-temporal cortex. In single human subjects MT+ has been subdivided in area MT, which was activated by motion stimuli in the contralateralvisualfield,andareaMST,whichrespondedtomotioninboththecontra-andipsilateralfield.Inthisstudywe investigatedthecorticalactivationwhenexcitatoryandinhibitoryinputsinterferewitheachotherinprimaryvisualregions andwepresentforthefirsttimegroupresultsoftheMT+subregions,allowingforcomparisonswiththegroupresultsof other motion processing studies. Using functional magnetic resonance imaging (fMRI), we investigated whole brain activations in a large group of healthy humans by applying optic flow stimuli in and near the visual field centre an