Organization of the pronephric kidney revealed by large-scale gene expression mapping 英文参考文献.docVIP

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Organization of the pronephric kidney revealed by large-scale gene expression mapping 英文参考文献.doc

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Organization of the pronephric kidney revealed by large-scale gene expression mapping 英文参考文献

Open Access Re rch 2008RacitietVoal.lumesea9, Issue 5, Article R84 Organization of the pronephric kidney revealed by large-scale gene expression mapping Daniela Raciti*, Luca Reggiani*, Lars Geffers?, Qiuhong Jiang?, Francesca Bacchion*, Astrid E Subrizi*, Dave Clements?, Christopher Tindal?, Duncan R Davidson?, Brigitte Kaissling§ and André W Br?ndli* Addresses: *Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zürich, Wolfgang-Pauli-Strasse 10, CH-8093 Zürich, Switzerland. ?Department of Genes and Behavior, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, D-37077 G?ttingen, Germany. ?MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK. §Institute of Anatomy, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland. Correspondence: André W Br?ndli. Email: brandli@pharma.ethz.ch Published: 20 May 2008 Received: 11 January 2008 Revised: 19 March 2008 Accepted: 20 May 2008 Genome Biology 2008, 9:R84 (doi:10.1186/gb-2008-9-5-r84) The electronic version of this article is the complete one and can be found online at /2008/9/5/R84 ? 2008 Raciti et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. XenopusthpemGaemnempronephroseaxlpiarenscsioolnlecmorganisationtiappingng ducrevealsis iden8tiffunctionallyied./p distinct domains in the Xenopus pronephros. Interestingly, no structure equivalent to Abstract Background: The pronephros, the simplest form of a vertebrate excretory organ, has recently become an important model of vertebrate kidney organogenesis. Here, we elucidated the nephron organization of the Xenopus pronephros and determined the similarities in segmentation with the metanephros, the adult kidne