Oriental schistosomiasis with neurological complications case report 英文参考文献.docVIP

Lietal.AnnalsofClinicalMicrobiologyandAntimicrobials2011,10:5 /content/10/1/5 CASE REPORT OpenAccess Orientalschistosomiasiswithneurological complications:casereport YueshengLi1,2*,AllenGRoss3,4,XunyaHou1,ZhaoyangLou1,DonaldPMcManus2 Abstract Wedescribeacaseofcerebralschistosomiasis,causedbyAsian(oriental)Schistosomajaponicumtrematodeblood flukes,inayoungChinesepatientanditsmanagement.Wealsoprovideabriefupdateforphysiciansonthe clinicalfeatures,diagnosisandtreatmentofschistosomiasis,withparticularemphasisonneuroschistosomiasis,the mostsevereclinicaloutcomeassociatedwiththisparasiticinfection. Background The Asian schistosome species (S. japonicum; Althoughnotcommonlyreportedinwesterncountries, S.mekongi)layupto3000eggsdailywiththeresulting schistosomiasisis,aftermalaria,thesecondmostpreva- morbidity being more severe than with the African lent tropical disease, affecting over 200 million people forms (S. mansoni; S. haematobium; S. intercalatum), [1]. It is an intravascular disease, caused by dioecious whichproducetentimesfewereggsperday[1,2].Mye- parasitic trematode worms of the genus Schistosoma. lopathy(acutetransversemyelitisandsubacutemyelora- Eggsreleasedbyadultfemalewormscausethemajority diculopathy) of the lumbosacral region is the most oflesionsinschistosomiasis whentheyembolizeinthe common neurological manifestation of S. mansoni or liver,spleen,lungs,orurino-genitalorcerebrospinalsys- S.haematobiuminfection,whereasacuteencephalopha- tems[1-3]. Eggsecretions provokeeosinophilic inflam- litis of the cortex, subcortex, basal ganglia or internal matory and granulomatous reactions which are capsuleistypicalofS.japonicum[1,2]. progressivelyreplacedbyfibroticdeposits[1,2].Schisto- Only a minority (5%) of patients will develop CNS somiasisisthusassociatedwithchronicliverandintest- symptomsduetoschistosomiasis,withcerebralcompli- inal or genitourinary tract fibrosis. Neurological cations being more prevalent than