Pasteurella multocida Involved in Respiratory Disease of Wild Chimpanzees 英文参考文献.docVIP

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Pasteurella multocida Involved in Respiratory Disease of Wild Chimpanzees 英文参考文献.doc

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Pasteurella multocida Involved in Respiratory Disease of Wild Chimpanzees 英文参考文献

PasteurellamultocidaInvolvedinRespiratoryDiseaseof WildChimpanzees SophieKo¨ndgen1,4*,MichaelaLeider1,FelixLankester2,AstridBethe3,AntinaLu¨bke-Becker3,FabianH. Leendertz1,ChristaEwers3 1ResearchGroupEmergingZoonoses,RobertKoch-Institut,Berlin,Germany,2ConservationandScienceDepartment,LincolnParkZoo,Chicago,Illinois,UnitedStatesof America,3VeterinaryFaculty,InstituteforMicrobiologyandEpizootics,FreieUniversitaetBerlin,Berlin,Germany,4DepartmentofPrimatology,MaxPlanckInstitutefor EvolutionaryAnthropology,Leipzig,Germany Abstract Pasteurellamultocidacancauseavarietyofdiseasesinvariousspeciesofmammalsandbirdsthroughouttheworldbut nothing is known about its importance for wild great apes. In this study we isolated P. multocida from wild living, habituatedchimpanzeesfromTa?¨NationalPark,Co?ted’Ivoire.Isolatesoriginatedfromtwochimpanzeesthatdiedduringa respiratory disease outbreak in 2004 as well as from one individual that developed chronic air-sacculitis following this outbreak. Four isolates were subjected to a full phenotypic and molecular characterisation. Two different clones were identifiedusingpulsedfieldgelelectrophoresis.MultiLocusSequenceTyping(MLST)enabledtheidentificationofprevious unknown alleles and two new sequence types, ST68 and ST69, were assigned. Phylogenetic analysis of the superoxide dismutase(sodA)geneandconcatenatedsequencesfromsevenMLST-housekeepinggenesshowedcloseclusteringwithin known P. multocida isolated from various hosts and geographic locations. Due to the clinical relevance of the strains described here, these results make an important contribution to our knowledge of pathogens involved in lethal disease outbreaksamongendangeredgreatapes. Citation:Ko¨ndgenS,LeiderM,LankesterF,BetheA,Lu¨bke-BeckerA,etal.(2011)PasteurellamultocidaInvolvedinRespiratoryDiseaseofWildChimpanzees.PLoS ONE6(9):e24236.doi:10.1371/journal.pone.0024236 Editor:EdgardoMoreno,UniversidadNacional,Heredia,CostaRica ReceivedMay20,2011;AcceptedAugust3,2011;PublishedSepte