Pch2 Links Chromosome Axis Remodeling at Future Crossover Sites and Crossover Distribution during Yeast Meiosis 英文参考文献.docVIP

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Pch2 Links Chromosome Axis Remodeling at Future Crossover Sites and Crossover Distribution during Yeast Meiosis 英文参考文献.doc

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Pch2 Links Chromosome Axis Remodeling at Future Crossover Sites and Crossover Distribution during Yeast Meiosis 英文参考文献

Pch2LinksChromosomeAxisRemodelingatFuture CrossoverSitesandCrossoverDistributionduringYeast Meiosis NeerajJoshi.,AekamBarot.,ChristineJamison,G.ValentinBo¨rner* CenterforGeneRegulationinHealthandDisease,DepartmentofBiological,Geological,andEnvironmentalSciences,ClevelandStateUniversity,Cleveland,Ohio,United StatesofAmerica Abstract Segregation of homologous chromosomes during meiosis I depends on appropriately positioned crossovers/chiasmata. Crossoverassuranceensuresatleastonecrossoverperhomologpair,whileinterferencereducesdoublecrossovers.Here, wehaveinvestigatedtheinterplaybetweenchromosomeaxismorphogenesisandnon-randomcrossoverplacement.We demonstrate that chromosome axes are structurally modified at future crossover sites as indicated by correspondence betweencrossoverdesignationmarkerZip3anddomainsenrichedforaxisensembleHop1/Red1.Thisassociationisfirst detectedatthezygotenestage,persistsuntildoubleHollidayjunctionresolution,andiscontrolledbytheconservedAAA+ ATPase Pch2. Pch2 further mediates crossover interference, although it is dispensable for crossover formation at normal levels. Thus, interference appears to be superimposed on underlying mechanisms of crossover formation. When recombination-initiating DSBs are reduced, Pch2 is also required for viable spore formation, consistent with further functionsinchiasmaformation.pch2DmutantdefectsincrossoverinterferenceandsporeviabilityatreducedDSBlevelsare oppositelymodulatedbytemperature,suggestingcontributionsoftwoseparablepathwaystocrossovercontrol.Rolesof Pch2 in controlling both chromosome axis morphogenesis and crossover placement suggest linkage between these processes.Pch2isproposedtoreorganizechromosomeaxesintoatilingarrayoflong-rangecrossovercontrolmodules, resultinginchiasmaformationatminimumlevelsandwithmaximumspacing. Citation:JoshiN,BarotA,JamisonC,Bo¨rnerGV(2009)Pch2LinksChromosomeAxisRemodelingatFutureCrossoverSitesandCrossoverDistributionduring YeastMeiosis.PLoSGenet5(7):e1000557.doi:10.1371/jou