Potential bias in testing for hyperprolactinemia and pituitary tumors in risperidone-treated patients a claims-based study 英文参考文献.docVIP

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Potential bias in testing for hyperprolactinemia and pituitary tumors in risperidone-treated patients a claims-based study 英文参考文献.doc

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Potential bias in testing for hyperprolactinemia and pituitary tumors in risperidone-treated patients a claims-based study 英文参考文献

Annals of General Psychiatry BioMedCentral Primary research Open Access Potential bias in testing for hyperprolactinemia and pituitary tumors in risperidone-treated patients: a claims-based study Frank D Gianfrancesco*1, Gahan Pandina2, Ramy Mahmoud3, Jasmanda Wu4 and Ruey H Wang1 Address: 1HECON Associates Inc., 9833 Whetstone Drive, Montgomery Village, MD 20886, USA, 2Johnson Johnson Pharmaceutical Research and Development, 1125 Trenton-Harbourton Road, Titusville, NJ 08560, USA, 3Ethicon, Inc. (a Johnson Johnson Company), PO Box 151, Route 22 West, Somerville, NJ 08876-0151, USA and 4Ortho-McNeil Janssen Scientific Affairs, LLC, 1125 Trenton-Harbourton Road, Titusville, NJ 08560, USA Email: Frank D Gianfrancesco* - frank_gianfrancesco@; Gahan Pandina - GPandina@; Ramy Mahmoud - RMahmou@ETHUS.; Jasmanda Wu - jasmanda_wu@; Ruey H Wang - rueyhua_wang@ * Corresponding author Published: 11 February 2009 Received: 7 May 2008 Accepted: 11 February 2009 Annals of General Psychiatry 2009, 8:5 doi:10.1186/1744-859X-8-5 This article is available from: /content/8/1/5 ? 2009 Gianfrancesco et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: A reporting association of risperidone with pituitary tumors has been observed. Because such tumors are highly prevalent, there may be other reasons why they were revealed in association with risperidone treatment. We assessed two potential explanations: disproportionately more prolactin assessment and head/brain imaging in risperidone-treated patients vs patients treated with other antipsychotics. Methods: Treatment episodes with risperidone, clozapine, olanzapine, quetiapine, ziprasidone, aripiprazole, haloperidol, perphenazine and other typical