Predictors for pathologically confirmed aortitis after resection of the ascending aorta A 12-year Danish nationwide population-based cross-sectional study 英文参考文献.docVIP
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Predictors for pathologically confirmed aortitis after resection of the ascending aorta A 12-year Danish nationwide population-based cross-sectional study 英文参考文献
Schmidtetal.ArthritisResearchTherapy2011,13:R87
/content/13/3/R87
RESEARCH ARTICLE
OpenAccess
Predictorsforpathologicallyconfirmedaortitis
afterresectionoftheascendingaorta:A12-year
Danishnationwidepopulation-based
cross-sectionalstudy
JeanSchmidt1,2*,KaareSunesen1,JetteBKornum1,PierreDuhaut2andReimarWThomsen1
Abstract
Introduction:Assessingtheprevalenceof,andpredictorsfor,pathologically-confirmedinflammationoftheaorta
inDenmark,usinganationwidepopulation-basedstudydesign.
Methods:Weidentifiedalladultswithfirst-timesurgeryontheascendingaortabetweenJanuary1,1997and
March1,2009inDenmark.Presenceofaorticinflammationwasascertainedthroughlinkagetoanationwide
pathologyregistry.Weusedlogisticregressiontocomputeprevalenceoddsratios(ORs)forsex,ageatsurgery,
cardiovascularriskfactors,cancer,connectivetissuedisease,andinfectiousdiseasesassociatedwiththepresenceof
aortitis.
Results:Atotalof1,210adultsunderwentresectionoftheascendingaorta,ofwho610(50.4%)hadtissue
submittedforpathologicalexamination.Aortitiswasfoundin37(6.1%)patientswhosetissuewasexamined.Ten
ofthe37patientswerediagnosedwithconditionsknowntobeassociatedwithaortitisoraorticaneurysm:five
patientswithtemporalarteritis,onewithCrohn’sdisease,onewithrheumatoidarthritis,onewithsystemiclupus
erythematosus,onewithinfectiousaortitis,andonewithMarfan’sdisease.Twenty-sevenpatientshadidiopathic
aortitis.Predictorsofaortitisincludedhistoryofconnectivetissuedisease(adjustedOR4.7,95%confidenceinterval
(CI)1.6,13.6),diabetes(OR5.2,95%CI0.9,29.7),advancedage(67yearsOR2.5,95%CI0.8,7.6),andaorticvalve
pathology(OR2.3,95%CI1.1,4.9).
Conclusions:Aortitiswaspresentin6.1%ofadultsinDenmarkwhohadpathologicalexaminationafterresection
oftheascendingaorta.Predictorsofinflammationincludedconnectivetissuedisease,diabetes,advancedage,and
aorticvalvepathology.
Introduction
considered, as aortitis may be a component of inflam-
Aortitis is defined as inflammation of the aortic wall matory diseases such as temporal arteritis [6] and
[1].Numerou
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