Predictors for pathologically confirmed aortitis after resection of the ascending aorta A 12-year Danish nationwide population-based cross-sectional study 英文参考文献.docVIP

Predictors for pathologically confirmed aortitis after resection of the ascending aorta A 12-year Danish nationwide population-based cross-sectional study 英文参考文献.doc

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Predictors for pathologically confirmed aortitis after resection of the ascending aorta A 12-year Danish nationwide population-based cross-sectional study 英文参考文献

Schmidtetal.ArthritisResearchTherapy2011,13:R87 /content/13/3/R87 RESEARCH ARTICLE OpenAccess Predictorsforpathologicallyconfirmedaortitis afterresectionoftheascendingaorta:A12-year Danishnationwidepopulation-based cross-sectionalstudy JeanSchmidt1,2*,KaareSunesen1,JetteBKornum1,PierreDuhaut2andReimarWThomsen1 Abstract Introduction:Assessingtheprevalenceof,andpredictorsfor,pathologically-confirmedinflammationoftheaorta inDenmark,usinganationwidepopulation-basedstudydesign. Methods:Weidentifiedalladultswithfirst-timesurgeryontheascendingaortabetweenJanuary1,1997and March1,2009inDenmark.Presenceofaorticinflammationwasascertainedthroughlinkagetoanationwide pathologyregistry.Weusedlogisticregressiontocomputeprevalenceoddsratios(ORs)forsex,ageatsurgery, cardiovascularriskfactors,cancer,connectivetissuedisease,andinfectiousdiseasesassociatedwiththepresenceof aortitis. Results:Atotalof1,210adultsunderwentresectionoftheascendingaorta,ofwho610(50.4%)hadtissue submittedforpathologicalexamination.Aortitiswasfoundin37(6.1%)patientswhosetissuewasexamined.Ten ofthe37patientswerediagnosedwithconditionsknowntobeassociatedwithaortitisoraorticaneurysm:five patientswithtemporalarteritis,onewithCrohn’sdisease,onewithrheumatoidarthritis,onewithsystemiclupus erythematosus,onewithinfectiousaortitis,andonewithMarfan’sdisease.Twenty-sevenpatientshadidiopathic aortitis.Predictorsofaortitisincludedhistoryofconnectivetissuedisease(adjustedOR4.7,95%confidenceinterval (CI)1.6,13.6),diabetes(OR5.2,95%CI0.9,29.7),advancedage(67yearsOR2.5,95%CI0.8,7.6),andaorticvalve pathology(OR2.3,95%CI1.1,4.9). Conclusions:Aortitiswaspresentin6.1%ofadultsinDenmarkwhohadpathologicalexaminationafterresection oftheascendingaorta.Predictorsofinflammationincludedconnectivetissuedisease,diabetes,advancedage,and aorticvalvepathology. Introduction considered, as aortitis may be a component of inflam- Aortitis is defined as inflammation of the aortic wall matory diseases such as temporal arteritis [6] and [1].Numerou

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