Prevalence of Grey Matter Pathology in Early Multiple Sclerosis Assessed by Magnetization Transfer Ratio Imaging 英文参考文献.docVIP

PrevalenceofGreyMatterPathologyinEarlyMultiple SclerosisAssessedbyMagnetizationTransferRatio Imaging LydieCrespy1,2,WafaaZaaraoui2,MathiasLemaire2,AudreyRico1,2,AnthonyFaivre2,Franc?oise Reuter1,2,IrinaMalikova1,2,SylvianeConfort-Gouny2,PatrickJ.Cozzone2,JeanPelletier1,2 ,Jean- PhilippeRanjeva2,BertrandAudoin1,2* 1Po?ledeNeurosciencesCliniques,ServicedeNeurologie,AssistancePubliqueHo?pitauxdeMarseille,CHUTimone,Marseille,France,2CentredeRe′sonanceMagne′tique BiologiqueetMe′dicale(CRMBM)UMRCNRS6612,Faculte′ deMe′decine,Universite′ delaMe′diterrane′e, Aix-MarseilleII,Marseille,France Abstract The aim of the study was to assess the prevalence, the distribution and the impact on disability of grey matter (GM) pathologyinearlymultiplesclerosis.Eighty-eightpatientswithaclinicallyisolatedsyndromewithahighriskdeveloping multiple sclerosis were included in the study. Forty-four healthy controls constituted the normative population. An optimizedstatisticalmappinganalysiswasperformed tocompareeachsubject’sGMMagnetizationTransferRatio(MTR) imaging maps with those of the whole group of controls. The statistical threshold of significant GM MTR decrease was determinedasthemaximumpvalue(p,0.05FDR)forwhichnosignificantclustersurvivedwhencomparingeachcontrol tothe wholecontrol population. Usingthis threshold, 51% of patients showedGM abnormalities comparedto controls. Locally,37%ofpatientspresentedabnormalitiesinsidethelimbiccortex,34%inthetemporalcortex,32%inthedeepgrey matter,30%inthecerebellum,30%inthefrontalcortex,26%intheoccipitalcortexand19%intheparietalcortex.Stepwise regressionanalysisevidencedsignificantassociation(p=0.002)betweenEDSSandbothGMpathology(p=0.028)andT2 whitematterlesionsload(p=0.019).Inthepresentstudy,weevidencedthatindividualanalysisofGMMTRmapallowed demonstrating thatGM pathologyis highlyheterogeneous across patients at theearlystageof MSand partlyunderlies irreversibledisability. Citation: Crespy L, Zaaraoui W, Lemaire M, Rico A, Faivre A, et al.