Prognostic Value of [18F]-Fluoro-Deoxy-Glucose PETCT, S100 or MIA for Assessment of Cancer-Associated Mortality in Patients with High Risk Melanoma 英文参考文献.docVIP

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Prognostic Value of [18F]-Fluoro-Deoxy-Glucose PETCT, S100 or MIA for Assessment of Cancer-Associated Mortality in Patients with High Risk Melanoma 英文参考文献.doc

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Prognostic Value of [18F]-Fluoro-Deoxy-Glucose PETCT, S100 or MIA for Assessment of Cancer-Associated Mortality in Patients with High Risk Melanoma 英文参考文献

PrognosticValueof[18F]-Fluoro-Deoxy-GlucosePET/CT, S100orMIAforAssessmentofCancer-Associated MortalityinPatientswithHighRiskMelanoma MarkusEssler1*,AnnaLink1,BenedettaBelloni2,VesnaMirceva2,MichaelSouvatzoglou1 ,Markus Thaler4,BernhardHaller3,RuedigerHein2,BerndJ.Krause1 1Nuklearmedizinische Klinik und Poliklinik, Klinikum rechts-der-Isar, Technische Universita¨t Mu¨nchen, Mu¨nchen, Germany, 2Dermatologische Klinik und Poliklinik, Technische Universita¨t Mu¨nchen, Mu¨nchen, Germany, 3Institut fu¨r Medizinische Statistik und Epidmiologie, Technische Universita¨t Mu¨nchen, Mu¨nchen, Germany, 4Institutfu¨rKlinischeChemieundPathobiochemie,TechnischeUniversita¨t Mu¨nchen,Mu¨nchen,Germany Abstract Purpose:ToassesstheprognosticvalueofFDGPET/CTcomparedtothetumormarkersS100Bandmelanomainhibitory activity(MIA)inpatientswithhighriskmelanoma. Methods: Retrospective study in 125 consecutive patients with high risk melanoma that underwent FDG PET/CT for re- staging. Diagnostic accuracy and prognostic value was determined for FDG PET/CT as well as for S100B and MIA. As standardofreference,cytological,histological,PET/CTorMRIfollow-upfindingsaswellasclinicalfollow-upwereused. Results:Of125patients,FDGPET/CTwaspositivein62patients.37(29.6%)patientshadelevatedS100B(.100pg/ml)and 24(20.2%)hadelevatedMIA(.10pg/ml)values.OverallspecificitiesforFDGPET/CT,S100BandMIAwere96.8%(95%CI, 89.1%to99.1%), 85.7%(75.0% to92.3%), and95.2%(86.9%to98.4%),correspondingsensitivitieswere96.8%(89.0%to 99.1%),45.2%(33.4%to55.5%),and36.1%(25.2%to48.6%),respectively.Thenegativepredictivevalues(NPV)forPET/CT, S100B,andMIAwere96.8%(89.1%to99.1%),61.4%(50.9%to70.9%),and60.6%(50.8%to69.7%).Thepositivepredictive values (PPV) were 96.7% (89.0% to 99.1%), 75.7% (59.9% to 86.6%), and 88.0% (70.0% to 95.8%). Patients with elevated S100B-orMIAvaluesorPET/CTpositivefindingsshowedasignificantly(p,0.001each,univariateCoxregressionmodels) higherriskofmelanomaassociateddeathwhichwasincreased4.2-,6.5-or17.2-fold,resp