Psoriasis Patients Are Enriched for Genetic Variants That Protect against HIV-1 Disease 英文参考文献.docVIP

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Psoriasis Patients Are Enriched for Genetic Variants That Protect against HIV-1 Disease 英文参考文献.doc

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Psoriasis Patients Are Enriched for Genetic Variants That Protect against HIV-1 Disease 英文参考文献

PsoriasisPatientsAreEnrichedforGeneticVariantsThat ProtectagainstHIV-1Disease HaoyanChen1,GenkiHayashi1,OliviaY.Lai1,AlexanderDilthey2,PeterJ.Kuebler3,TamiV.Wong1, MaureenP.Martin4,MarceloA.FernandezVina5,GilMcVean2,MatthiasWabl6,KieronS.Leslie1 ,Toby Maurer1,JeffreyN.Martin7,StevenG.Deeks8,MaryCarrington4,AnneM.Bowcock9,DouglasF.Nixon3, WilsonLiao1* 1DepartmentofDermatology,UniversityofCaliforniaSanFrancisco,SanFrancisco,California,UnitedStatesofAmerica,2DepartmentofStatistics,UniversityofOxford, Oxford,United Kingdom, 3DivisionofExperimentalMedicine, University ofCalifornia San Francisco, SanFrancisco,California,United States ofAmerica, 4Cancerand InflammationProgram,Laboratory ofExperimentalImmunology, NationalCancerInstitute,Frederick,Maryland,UnitedStatesofAmerica, 5DepartmentofPathology, StanfordUniversity,PaloAlto,California,UnitedStatesofAmerica,6DepartmentofMicrobiologyandImmunology,UniversityofCaliforniaSanFrancisco,SanFrancisco, California, United States of America, 7Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, United States of America,8HIV/AIDSProgram,DepartmentofMedicine,UniversityofCaliforniaSanFrancisco,SanFrancisco,California,UnitedStatesofAmerica, 9DivisionofHuman Genetics,DepartmentofGenetics,WashingtonUniversitySchoolofMedicine,SaintLouis,Missouri,UnitedStatesofAmerica Abstract Animportantparadigminevolutionarygeneticsisthatofadelicatebalancebetweengeneticvariantsthatfavorablyboost hostcontrolofinfectionbutwhichmayunfavorablyincreasesusceptibilitytoautoimmunedisease.Here,weinvestigated whetherpatientswithpsoriasis,acommonimmune-mediateddiseaseoftheskin,areenrichedforgeneticvariantsthatlimit the ability of HIV-1 virus to replicate after infection. We analyzed the HLA class I and class II alleles of 1,727 Caucasian psoriasiscasesand3,581controlsandfoundthatpsoriasispatientsaresignificantlymorelikelythancontrolstohavegene variants that are protective against HIV-1