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Quantifying the Clinical Significance of Cannabis Withdrawal 英文参考文献
QuantifyingtheClinicalSignificanceofCannabis
Withdrawal
DavidJ.Allsop1*,JanCopeland1,MelissaM.Norberg1,ShanlinFu2,AnnaMolnar2,JohnLewis2,
AlanJ.Budney3
1 National Cannabis Prevention and Information Centre, National Drug and Alcohol Research Centre, University of New South Wales, Sydney, New South Wales, Australia,
2 Centre for Forensic Science, School of Chemistry and Forensic Science, University of Technology Sydney (UTS), New South Wales, Australia,3 Geisel School of Medicine
at Dartmouth, Hanover, Lebanon, New Hampshire, United States of America
Abstract
Background and Aims: Questions over the clinical significance of cannabis withdrawal have hindered its inclusion as a
discrete cannabis induced psychiatric condition in the Diagnostic and Statistical Manual of Mental Disorders (DSM IV). This
study aims to quantify functional impairment to normal daily activities from cannabis withdrawal, and looks at the factors
predicting functional impairment. In addition the study tests the influence of functional impairment from cannabis
withdrawal on cannabis use during and after an abstinence attempt.
Methods and Results: A volunteer sample of 49 non-treatment seeking cannabis users who met DSM-IV criteria for
dependence provided daily withdrawal-related functional impairment scores during a one-week baseline phase and two
weeks of monitored abstinence from cannabis with a one month follow up. Functional impairment from withdrawal
symptoms was strongly associated with symptom severity (p = 0.0001). Participants with more severe cannabis dependence
before the abstinence attempt reported greater functional impairment from cannabis withdrawal (p = 0.03). Relapse to
cannabis use during the abstinence period was associated with greater functional impairment from a subset of withdrawal
symptoms in high dependence users. Higher levels
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