Replication of the genetic effects of IFN regulatory factor 5 (IRF5) on systemic lupus erythematosus in a Korean population 英文参考文献.docVIP

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Replication of the genetic effects of IFN regulatory factor 5 (IRF5) on systemic lupus erythematosus in a Korean population 英文参考文献.doc

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Replication of the genetic effects of IFN regulatory factor 5 (IRF5) on systemic lupus erythematosus in a Korean population 英文参考文献

Available online /content/9/2/R32 Research article Open Access Vol 9 No 2 Replication of the genetic effects of IFN regulatory factor 5 (IRF5) on systemic lupus erythematosus in a Korean population Hyoung Doo Shin1, Yoon-Kyoung Sung2, Chan-Bum Choi2, Soo Ok Lee1, Hye Won Lee1 and Sang-Cheol Bae2 1Department of Genetic Epidemiology, SNP Genetics Inc., Rm 1407, 14th floor, Complex B, WooLim Lions Valley, 371-28, Gasan-Dong, Geumcheon-Gu, Seoul 153-801, Korea 2Department of Internal Medicine, Division of Rheumatology, Hospital for Rheumatic Diseases, Hanyang University, 17 Hangdang Dong, Sungdong- Gu, Seoul 133-792, Korea Corresponding author: Sang-Cheol Bae, scbae@hanyang.ac.kr Received: 22 Jan 2007 Revisions requested: 16 Feb 2007 Revisions received: 12 Mar 2007 Accepted: 27 Mar 2007 Published: 27 Mar 2007 Arthritis Research Therapy 2007, 9:R32 (doi:10.1186/ar2152) This article is online at: /content/9/2/R32 ? 2007 Shin et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Recently, two studies provided convincing evidence that IFN regulatory factor 5 (IRF5) gene polymorphisms are significantly associated with systemic lupus erythematosus (SLE) in several white populations. To replicate the association with SLE in an Asian population, we examined the genetic effects in our SLE cohort from a Korean population. A total of 1,565 subjects, SLE cases (0.385) than controls (0.321; odds ratio (OR) = 1.32, P = 0.0003). In combined analysis, including all seven independent cohorts from the three studies so far, robust and consistent associations of the rs2004640 T allele with SLE were observed. The estimate of risk was OR = 1.44 (range, 1.34–1.55), with an overall P = 1.85 × 10-23 for t