Replication of Putative Susceptibility Loci from Genome-Wide Association Studies Associated with Coronary Atherosclerosis in Chinese Han Population 英文参考文献.docVIP

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Replication of Putative Susceptibility Loci from Genome-Wide Association Studies Associated with Coronary Atherosclerosis in Chinese Han Population 英文参考文献.doc

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Replication of Putative Susceptibility Loci from Genome-Wide Association Studies Associated with Coronary Atherosclerosis in Chinese Han Population 英文参考文献

ReplicationofPutativeSusceptibilityLocifromGenome- WideAssociationStudiesAssociatedwithCoronary AtherosclerosisinChineseHanPopulation FangXie1,2.,XunChu1,2.,HongWu3.,WeiweiSun2,MinShen2,LinYang2,YingWang2,YiWang2 ,Jinxiu Shi2,WeiHuang1,2* 1RuijinHospital,SchoolofMedicine,ShanghaiJiaotongUniversity,Shanghai,China,2Shanghai-MOSTKeyLaboratoryofHealthandDiseaseGenomics,Departmentof Genetics,ChineseNationalHumanGenomeCenter,Shanghai,China,3DepartmentofCardiology,ChanghaiHospital,TheSecondMilitaryMedicalUniversity,Shanghai, China Abstract Background:Coronaryatherosclerosis,themaincauseofcardiovasculardisease,isaprogressivedisease.RecentGenome WideAssociationStudies(GWASs)discoveredseveralnovellociassociatedwithcoronaryarterydisease(CAD)oritsmain complicationmyocardialinfarction(MI).Inthisstudy,weinvestigatedtheassociationsbetweenpreviouslyreportedCAD- andMI-associatedvariantsandcoronaryatherosclerosisinChineseHanpopulation. Methodology/Principal Findings: We performed a case-control association study with 2,335 coronary atherosclerosis patients and 1,078 controls undergoing coronary angiography of Chinese Han from China. Fourteen single nucleotide polymorphisms (SNPs), located at 1p13.3, 1q41, 2q36.3, 6q25.1, 9p21.3, 10q11.21 and 15q22.33, were genotyped in our sample collection. Six SNPs at 9p21 were associated with coronary atherosclerosis susceptibility (Ptrend,0.05) and rshowed the most significant association (P=2 OR=1.34). These associations remained significant after adjustment for multiple comparisons. Rat 1q41 (Ptrend=6 OR=0.86) also showed significant associationwithcoronaryatherosclerosis,buttheassociationwasnotsignificantaftermultiplecomparisons.Additionally, rs501120(P=8OR=0.80)at10q11.21wasassociatedwithcoronaryatherosclerosisinfemales,butdidnotshow association in males and all participants. Variants at 1p13.3, 2q36.3, 6q25.1 and 15q22.33 showed no associations with coronaryatherosclerosisandmaincardiovascu