Risk Factors and Immunity in a Nationally Representative Population following the 2009 Influenza A(H1N1) Pandemic 英文参考文献.docVIP

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Risk Factors and Immunity in a Nationally Representative Population following the 2009 Influenza A(H1N1) Pandemic 英文参考文献.doc

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Risk Factors and Immunity in a Nationally Representative Population following the 2009 Influenza A(H1N1) Pandemic 英文参考文献

RiskFactorsandImmunityinaNationallyRepresentative Populationfollowingthe2009InfluenzaA(H1N1) Pandemic DonBandaranayake1,Q.SueHuang1*,AngeBissielo1,TimWood1,GrahamMackereth2,MichaelG. Baker3,RichardBeasley4,StewartReid5,SallyRoberts6,VirginiaHope1,onbehalfofthe2009H1N1 serosurveyinvestigationteam 1InstituteofEnvironmentalScienceandResearch,NationalCentreforBiosecurityandInfectiousDisease,UpperHutt,NewZealand,2MinistryofHealth,Wellington,New Zealand,3WellingtonSchoolofMedicine,UniversityofOtago,Wellington,NewZealand,4MedicalResearchInstituteofNewZealand,WellingtonHospital,Wellington, NewZealand,5RopataMedicalCentre,LowerHutt,NewZealand,6DepartmentofMicrobiology,AucklandDistrictHealthBoard,Auckland,NewZealand Abstract Background: Understanding immunity, incidence and risk factors of the 2009 influenza A(H1N1) pandemic (2009 H1N1) throughanationalseroprevalencestudyisnecessaryforinformingpublichealthinterventionsanddiseasemodelling. Methods and Findings: We collected 1687 serum samples and individual risk factor data between November-2009 to March-2010,threemonthsaftertheendofthe2009H1N1waveinNewZealand.Participantswererandomlysampledfrom selectedgeneralpracticescountrywideandhospitalsintheAucklandregion.Baselineimmunitywasmeasuredfrom521 seracollectedduring2004toApril-2009.Haemagglutinationinhibition(HI)antibodytitresof$1:40against2009H1N1were considered seroprotective as well as seropositive. The overall community seroprevalence was 26.7% (CI:22.6–29.4). The seroprevalencevariedacrossageandethnicity.Childrenaged5–19yearshadthehighestseroprevalence(46.7%;CI:38.3– 55.0), a significant increase from the baseline (14%;CI:7.2–20.8). Older adults aged $60 had no significant difference in seroprevalence between the serosurvey (24.8%;CI:18.7–30.9) and baseline (22.6%;CI:15.3–30.0). Pacific peoples had the highestseroprevalence(49.5%;CI:35.1–64.0).Therewasnosignificantdifferenceinseroprevalencebetweenbothprimary (29.6%;CI:22.6–36.5) and secondary healthcare workers (25.3%;CI