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Robust Peak Recognition in Intracranial Pressure Signals 英文参考文献
RobustPeakRecognitioninIntracranialPressure
Signals
Scalzoetal.
Scalzoetal.BioMedicalEngineeringOnLine2010,9:61
/content/9/1/61(19October2010)
Scalzoetal.BioMedicalEngineeringOnLine2010,9:61
/content/9/1/61
RESEARCH
OpenAccess
RobustPeakRecognitioninIntracranial
PressureSignals
FabienScalzo*,ShadnazAsgari,SunghanKim,MarvinBergsneider,XiaoHu*
*Correspondence:
Abstract
fscalzo@;
xhu@
Background:Thewaveformmorphologyofintracranialpressurepulses(ICP)isan
essentialindicatorformonitoring,andforecastingcriticalintracranialand
cerebrovascularpathophysiologicalvariations.WhilecurrentICPpulseanalysis
frameworksoffersatisfyingresultsonmostofthepulses,weobservedthatthe
performanceofseveralofthemdeterioratessignificantlyonabnormal,orsimply
morechallengingpulses.
DepartmentofNeurosurgery,
GeffenSchoolofMedicine,Neural
SystemsandDynamicLab(NSDL),
UniversityofCalifornia,Los
Angeles,CA,USA
Methods:Thispaperprovidestwocontributionstothisproblem.First,itintroduces
MOCAIP++,agenericICPpulseprocessingframeworkthatgeneralizesMOCAIP
(MorphologicalClusteringandAnalysisofICPPulse).Itsstrengthistointegrate
severalpeakrecognitionmethodstodescribeICPmorphology,andtoexploit
differentICPfeaturestoimprovepeakrecognition.Second,itinvestigatestheeffect
ofincorporating,automaticallyidentified,challengingpulsesintothetrainingsetof
peakrecognitionmodels.
Results:ExperimentsonalargedatasetofICPsignals,aswellasonarepresentative
collectionofsampledchallengingICPpulses,demonstratethatbothcontributions
arecomplementaryandsignificantlyimprovepeakrecognitionperformancein
clinicalconditions.
Conclusion:Theproposedframeworkallowstoextractmorereliablestatisticsabout
theICPwaveformmorphologyonchallengingpulsestoinvestigatethepredictive
powerofthesepulsesontheconditionofthepatient.
1Background
Traumatic Brain Injuries (TBI) affect more than 2 million people annually in the
UnitedStates,andtheirincidenceintheworldkeepsincreasing[1].Thetreatmentof
TBIpatientsincriticalcareunits,aswellasotherneurologicaldisorde
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