Robust Reproducible Resting State Networks in the Awake Rodent Brain 英文参考文献.docVIP

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Robust Reproducible Resting State Networks in the Awake Rodent Brain 英文参考文献.doc

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Robust Reproducible Resting State Networks in the Awake Rodent Brain 英文参考文献

RobustReproducibleRestingStateNetworksinthe AwakeRodentBrain LinoBecerra*,GautamPendse,Pei-ChingChang,JamesBishop,DavidBorsook PainandAnalgesiaImagingNeuroscienceGroup,A.A.MartinosCenterforBiomedicalImaging,MassachusettsGeneralHospital,Boston,Massachusetts,UnitedStatesof America Abstract Restingstatenetworks(RSNs)havebeenstudiedextensivelywithfunctionalMRIinhumansinhealthanddiseasetoreflect brainfunctionintheun-stimulatedstateaswellasrevealhowthebrainisalteredwithdisease.Rodentmodelsofdisease havebeenusedcomprehensivelytounderstandthebiologyofthediseaseaswellasinthedevelopmentofnewtherapies. RSNreportedstudiesinrodents,however,arefew,andmoststudiesareperformedwithanesthetizedrodentsthatmight alternetworksanddifferfromtheirnon-anesthetizedstate.AcquiringRSNdataintheawakerodentavoidstheissuesof anesthesia effects on brain function. Using high field fMRI we determined RSNs in awake rats using an independent component analysis (ICA) approach, however, ICA analysis can produce a large number of components, some with biological relevance (networks). We further have applied a novel method to determine networks that are robust and reproducibleamongallthecomponentsfoundwithICA.Thisanalysisindicatesthat7networksarerobustandreproducible intheratandtheirputativeroleisdiscussed. Citation:BecerraL,PendseG,ChangP-C,BishopJ,BorsookD(2011)RobustReproducibleRestingStateNetworksintheAwakeRodentBrain.PLoSONE6(10): e25701.doi:10.1371/journal.pone.0025701 Editor:YongHe,BeijingNormalUniversity,Beijing,China ReceivedJuly8,2011;AcceptedSeptember8,2011;PublishedOctober18,2011 Copyright: ? 2011 Becerra et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding:TheworkwassupportedbyNationalInstituteofDrugAbuse(grantnumberK24NS064050-DB)andTheHerlandsFundforPainResearch(DB,LB).The projectdescribedwassupportedbyAwardNumbe