Selecting short-statured children needing growth hormone testing Derivation and validation of a clinical decision rule 英文参考文献.docVIP

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Selecting short-statured children needing growth hormone testing Derivation and validation of a clinical decision rule 英文参考文献.doc

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Selecting short-statured children needing growth hormone testing Derivation and validation of a clinical decision rule 英文参考文献

BMC Pediatrics BioMedCentral Research article Open Access Selecting short-statured children needing growth hormone testing: Derivation and validation of a clinical decision rule La?titia Duché1,2,3, Christine Trivin4, Wassim Chemaitilly3, Jean Claude Souberbielle4, Gérard Bréart2, Raja Brauner3 and Martin Chalumeau*1,2 Address: 1Clinical Epidemiological Unit-Department of Pediatrics, Saint-Vincent-de-Paul Hospital, AP-HP, Université Paris Descartes, 75014 Paris, France, 2INSERM U149, 75014 Paris, France, 3Université Paris Descartes and Assistance Publique H?pitaux de Paris, H?pital Bicêtre, Unité dendocrinologie pédiatrique, 94270 Le Kremlin Bicêtre, France and 4Assistance Publique H?pitaux de Paris, Necker-Enfants Malades Hospital, Service dexplorations fonctionnelles, 75743 Paris, France Email: La?titia Duché - laetitia.duche@; Christine Trivin - christine.trivin@nck.ap-hop-paris.fr; Wassim Chemaitilly - wchemaitilly@; Jean Claude Souberbielle - jean-claude.souberbielle@nck.ap-hop-paris.fr; Gérard Bréart - breart@cochin.inserm.fr; Raja Brauner - raja.brauner@wanadoo.fr; Martin Chalumeau* - martin.chalumeau@svp.aphp.fr * Corresponding author Published: 16 July 2008 Received: 13 January 2008 Accepted: 16 July 2008 BMC Pediatrics 2008, 8:29 doi:10.1186/1471-2431-8-29 This article is available from: /1471-2431/8/29 ? 2008 Duché et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Numerous short-statured children are evaluated for growth hormone (GH) deficiency (GHD). In most patients, GH provocative tests are normal and are thus in retrospect unnecessary. Methods: A retrospective cohort study was conducted to identify predictors of growth hormone (GH) deficiency (GHD) in children see