Serum Amyloid P Therapeutically Attenuates Murine Bleomycin-Induced Pulmonary Fibrosis via Its Effects on Macrophages 英文参考文献.docVIP

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Serum Amyloid P Therapeutically Attenuates Murine Bleomycin-Induced Pulmonary Fibrosis via Its Effects on Macrophages 英文参考文献.doc

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Serum Amyloid P Therapeutically Attenuates Murine Bleomycin-Induced Pulmonary Fibrosis via Its Effects on Macrophages 英文参考文献

SerumAmyloidPTherapeuticallyAttenuatesMurine Bleomycin-InducedPulmonaryFibrosisviaItsEffectson Macrophages LynneA.Murray1*,RogerioRosada2,AnaPaulaMoreira2,AmritaJoshi2,MichaelS.Kramer1,DavidP. Hesson1,RochelleL.Argentieri1,SusanMathai3,MriduGulati3,EricaL.Herzog3,CoryM.Hogaboam2 1Promedior,Inc.,Malvern,Pennsylvania,UnitedStatesofAmerica,2DepartmentofPathology,UniversityofMichiganMedicalSchool,AnnArbor,Michigan,UnitedStates ofAmerica,3InternalMedicine,PulmonaryandCriticalCareDivision,YaleUniversitySchoolofMedicine,NewHaven,Connecticut,UnitedStatesofAmerica Abstract Macrophagespromotetissueremodelingbutfewmechanismsexisttomodulatetheiractivityduringtissuefibrosis.Serum amyloidP(SAP),amemberofthepentraxinfamilyofproteins,signalsthroughFccreceptorswhichareknowntoaffect macrophageactivation.WedeterminedthatIPF/UIPpatientshaveincreasedproteinlevelsofseveralalternativelyactivated pro-fibrotic(M2)macrophage-associatedproteinsinthelungandmonocytesfromthesepatientsshowskewingtowardsan M2 macrophage phenotype. SAP therapeutically inhibits established bleomycin-induced pulmonary fibrosis, when administered systemically or locally to the lungs. The reduction in aberrant collagen deposition was associated with a reduction in M2 macrophages in the lung and increased IP10/CXCL10. These data highlight the role of macrophages in fibrotic lung disease, anddemonstrateatherapeutic actionof SAPon macrophages which may extend tomanyfibrotic indicationscausedbyover-exuberantpro-fibroticmacrophageresponses. Citation:MurrayLA,RosadaR,MoreiraAP,JoshiA,KramerMS,etal.(2010)SerumAmyloidPTherapeuticallyAttenuatesMurineBleomycin-InducedPulmonary FibrosisviaItsEffectsonMacrophages.PLoSONE5(3):e9683.doi:10.1371/journal.pone.0009683 Editor:CarolFeghali-Bostwick,UniversityofPittsburgh,UnitedStatesofAmerica ReceivedDecember11,2009;AcceptedFebruary21,2010;PublishedMarch12,2010 Copyright: ? 2010 Murray et al. This is an open-access article distributed under the terms of the Creative Commons Attributi