Serologic Survey of the Pandemic H1N1 2009 Virus in Guangdong Province, China A Cross Sectional Study 英文参考文献.docVIP

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Serologic Survey of the Pandemic H1N1 2009 Virus in Guangdong Province, China A Cross Sectional Study 英文参考文献.doc

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Serologic Survey of the Pandemic H1N1 2009 Virus in Guangdong Province, China A Cross Sectional Study 英文参考文献

SerologicSurveyofthePandemicH1N12009Virusin GuangdongProvince,China:ACrossSectionalStudy XinZhang*.,JianfengHe.,LinghuiLi.,XiaolanZhu,ChangwenKe,HanzhongNi,NianmeiHou,Haojie Zhong,JieWu CenterforDiseaseControlandPreventionofGuangdongProvince,Guangzhou,People’sRepublicofChina Abstract Background: Relying on surveillance of clinical cases limits the ability to understand the full impact and severity of an epidemic,whichurgesadeepinsightintotheserologicalevidenceofinfectionandtransmissionfeatureofpandemicH1N1 2009(pH1N1)virusinGuangdongprovince. Methods:Inthiscross-sectionalserologicalsurvey,serumsampleswerecollectedbymulti-stagestratifiedrandomsampling in Jan 2010. Antibody titers were measured by hemagglutination inhibition (HI) assay. Age-specific and region-specific prevalencewerecalculatedbasedontheresultsofHIassay(positive,HItiter$1:40). Results: Atotal of4,319 serum samples hadbeencollected fromsubjects withoutvaccination withpH1N1 vaccine. The seroprevalence was 22.82% (985/4,319). By contrast, there was a marked spatial heterogeneity in prevalence. The seroprevalencewas27.3%inlargecity,21.4%inmediumcities,higherthanthatof20.2%inruralareas.Theseroprevalence washighestin11–20agegroup(32.8%),however,inthoseabove60yearsofagegroup,whichwas12.6%,lowerthanother agegroups.Ontheotherhand,antibodytiterstopH1N1viruswerehighestinschoolchildren,whichwerefollowedbya gradualdecreaseinadult.However,intheelderlygroupsfromcities,especiallyfromlargecity,theantibodytitertopH1N1 increasedsignificantlyandreachedamuchhigherlevel. Conclusion:OurresultsshowedthattheprevalenceforpH1N1wascorrelatedwithageandpopulationdensity.Preexisting antibodymayhaveprotectedtheveryoldfrompH1N1infection,whileoriginalantigenicsinandimmunosenescencemay have contributed to greater severity once infected. These should be considered when studying the pathogenesis and transmissionofinfluenzavirusandformulatingstrategiesonvaccinationandtreatment. Citation: ZhangX,HeJ,LiL,ZhuX,KeC,etal.(2011)SerologicSurve