Sildenafil Enhances Neurogenesis and Oligodendrogenesis in Ischemic Brain of Middle-Aged Mouse 英文参考文献.docVIP

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Sildenafil Enhances Neurogenesis and Oligodendrogenesis in Ischemic Brain of Middle-Aged Mouse 英文参考文献.doc

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Sildenafil Enhances Neurogenesis and Oligodendrogenesis in Ischemic Brain of Middle-Aged Mouse 英文参考文献

SildenafilEnhancesNeurogenesisand OligodendrogenesisinIschemicBrainofMiddle-Aged Mouse RuiLanZhang1,MichaelChopp1,2,CynthiaRoberts1,MinWei1,XinliWang1,XianshuangLiu1,MeiLu3, ZhengGangZhang1* 1Department ofNeurology,Henry FordHospital,Detroit, Michigan, United Statesof America, 2Physics Department, Oakland University, Rochester, Michigan, United StatesofAmerica,3DepartmentofBiostatisticsandResearchEpidemiology,HenryFordHospital,Detroit,Michigan,UnitedStatesofAmerica Abstract Adultneuralstemcellsgiverisetoneurons,oligodendrocytesandastrocytes.Agingreducesneuralstemcells.Usingan inducible nestin-CreERT2/R26R-yellow fluorescent protein (YFP) mouse, we investigated the effect of Sildenafil, aphosphodiesterasetype5(PDE5)inhibitor,onnestinlineageneuralstemcellsandtheirprogenyintheischemicbrain of the middle-aged mouse. We showed that focal cerebral ischemia induced nestin lineage neural stem cells in the subventricularzone(SVZ)ofthelateralventriclesandnestinexpressingNeuNpositiveneuronsandadenomatouspolyposis coli(APC)positivematureoligodendrocytesintheischemicstriatumandcorpuscallosumintheagedmouse.Treatmentof the ischemic middle-aged mouse with Sildenafil increased nestin expressing neural stem cells, mature neurons, and oligodendrocytesby33,75,and30%,respectively,intheischemicbrain.ThesedataindicatethatSildenafilamplifiesnestin expressing neural stem cells and their neuronal and oligodendrocyte progeny in the ischemic brain of the middle-aged mouse. Citation:ZhangRL,ChoppM,RobertsC,WeiM,WangX,etal.(2012)SildenafilEnhancesNeurogenesisandOligodendrogenesisinIschemicBrainofMiddle- AgedMouse.PLoSONE7(10):e48141.doi:10.1371/journal.pone.0048141 Editor:CesarVBorlongan,UniversityofSouthFlorida,UnitedStatesofAmerica ReceivedJuly11,2012;AcceptedSeptember19,2012;PublishedOctober31,2012 Copyright: ? 2012 Zhang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproducti