Silencing SOX2 Induced Mesenchymal-Epithelial Transition and Its Expression Predicts Liver and Lymph Node Metastasis of CRC Patients 英文参考文献.docVIP

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Silencing SOX2 Induced Mesenchymal-Epithelial Transition and Its Expression Predicts Liver and Lymph Node Metastasis of CRC Patients 英文参考文献.doc

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SilencingSOX2InducedMesenchymal-Epithelial TransitionandItsExpressionPredictsLiverandLymph NodeMetastasisofCRCPatients XuHan1,XuefengFang4,XiaoyanLou1,DasongHua1,WenchaoDing1,GregoryFoltz2,LeroyHood3, YingYuan4*,BiaoyangLin1,2,5* 1SystemsBiologyDivision,Zhejiang–CaliforniaInternationalNanosystemsInstitute,ZhejiangUniversity,Hangzhou,Zhejiang,China,2SwedishNeuroscience Institute, SwedishMedicalCenter,Seattle,Washington,UnitedStatesofAmerica,3TheInstituteforSystemsBiology,Seattle,Washington,UnitedStatesofAmerica,4Department ofMedicalOncology,The2ndHospitalofZhejiangUniversityMedicalCollege,Hangzhou,Zhejiang,China,5DepartmentofUrology,UniversityofWashington,Seattle, Washington,UnitedStatesofAmerica Abstract SOX2isanimportantstemcellmarkerandplaysimportantrolesindevelopmentandcarcinogenesis.However,theroleof SOX2 in Epithelial-Mesenchymal Transition has not been investigated. We demonstrated, for the first time, that SOX2 is involvedintheEpithelial-MesenchymalTransition(EMT)processasknockdownofSOX2incolorectalcancer(CRC)SW620 cellsinducedaMesenchymal-EpithelialTransition(MET)processwithrecognizedchangesintheexpressionofkeygenes involvedintheEMTprocessincludingE-cadherinandvimentin.Inaddition,weprovidedalinkbetweenSOX2activityand theWNTpathwaybyshowingthatknockdownofSOX2reducedtheWNTpathwayactivityincolorectalcancer(CRC)cells. WefurtherdemonstratedthatSOX2isinvolvedincellmigrationandinvasioninvitroandinmetastasisinvivoforCRCcells, andthattheprocessmightbemediatedthroughtheMMP2activity.Finally,anIHCanalysisof44casesofcolorectalcancer patientssuggestedthatSOX2isaprognosismarkerformetastasisofcolorectalcancers. Citation:HanX,FangX,LouX,HuaD,DingW,etal.(2012)SilencingSOX2InducedMesenchymal-EpithelialTransitionandItsExpressionPredictsLiverand LymphNodeMetastasisofCRCPatients.PLoSONE7(8):e41335.doi:10.1371/journal.pone.0041335 Editor:MichaelKlymkowsky,UniversityofColoradoBoulder,UnitedStatesofAmerica ReceivedDecember2,2011;AcceptedJune25,2012;PublishedAugust17,2012 Cop