Simulation of Near-Infrared Light Absorption Considering Individual Head and Prefrontal Cortex Anatomy Implications for Optical Neuroimaging 英文参考文献.docVIP

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Simulation of Near-Infrared Light Absorption Considering Individual Head and Prefrontal Cortex Anatomy Implications for Optical Neuroimaging 英文参考文献.doc

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Simulation of Near-Infrared Light Absorption Considering Individual Head and Prefrontal Cortex Anatomy Implications for Optical Neuroimaging 英文参考文献

SimulationofNear-InfraredLightAbsorption ConsideringIndividualHeadandPrefrontalCortex Anatomy:ImplicationsforOpticalNeuroimaging FlorianB.Haeussinger1.,SebastianHeinzel1,2,3*.,TimHahn2,4,MartinSchecklmann5 ,Ann-Christine Ehlis1,AndreasJ.Fallgatter1 1DepartmentofPsychiatryandPsychotherapy,UniversityofTuebingen,Tuebingen,Germany,2DepartmentofPsychiatry,PsychosomaticsandPsychotherapy,University ofWuerzburg,Wuerzburg,Germany,3GermanCenterforNeurodegenerativeDiseases(DZNE),Bonn,Germany,4DepartmentofCognitivePsychologyII,Universityof FrankfurtamMain,FrankfurtamMain,Germany,5DepartmentofPsychiatryandPsychotherapy,UniversityofRegensburg,Regensburg,Germany Abstract Functional near-infrared spectroscopy (fNIRS) is an established optical neuroimaging method for measuring functional hemodynamicresponsestoinferneuralactivation.However,theimpactofindividualanatomyonthesensitivityoffNIRS measuringhemodynamicswithincorticalgraymatterisstillunknown.BymeansofMonteCarlosimulationsandstructural MRIof23healthysubjects(meanage:(25:0+2:8)years),wecharacterizedtheindividualdistributionoftissue-specificNIR- light absorption underneath 24 prefrontal fNIRS channels. We, thereby, investigated the impact of scalp-cortex distance (SCD),frontalsinusvolumeaswellassulcalmorphologyongraymattervolumes(Vgray)traversedbyNIR-light,i.e.anatomy- dependent fNIRS sensitivity. The NIR-light absorption between optodes was distributed describing a rotational ellipsoid withameanpenetrationdepthof(23:6+0:7)mmconsideringthedeepest5%oflight.Ofthedetectedphotonpackages scalp and bone absorbed (96:4+9:7)% and Vgray absorbed (3:1+1:8)% of the energy. The mean Vgray volume (1:1+0:4)cm3 wasnegativelycorrelated(r~{:76)withtheSCDandfrontalsinusvolume(r~{:57)andwasreducedby 41:5% in subjects with relatively large compared to small frontal sinus. Head circumference was significantly positively correlatedwiththemeanSCD(r~:46)andthetraversedfrontalsinusvolume(r~:43).Sulcalmorphologyhadnosignificant impactonVgray.Ourfinding