Sparse Representation of Brain Aging Extracting Covariance Patterns from Structural MRI 英文参考文献.docVIP

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Sparse Representation of Brain Aging Extracting Covariance Patterns from Structural MRI 英文参考文献.doc

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Sparse Representation of Brain Aging Extracting Covariance Patterns from Structural MRI 英文参考文献

SparseRepresentationofBrainAging:Extracting CovariancePatternsfromStructuralMRI LongfeiSu,LubinWang,FanglinChen,HuiShen,BaojuanLi,DewenHu* CollegeofMechatronicsandAutomation,NationalUniversityofDefenseTechnology,Changsha,Hunan,People’sRepublicofChina Abstract An enhanced understanding of how normal aging alters brain structure is urgently needed for the early diagnosis and treatment of age-related mental diseases. Structural magnetic resonance imaging (MRI) is a reliable technique used to detectage-relatedchangesinthehumanbrain.Currently,multivariatepatternanalysis(MVPA)enablestheexplorationof subtleanddistributedchangesofdataobtainedfromstructuralMRIimages.Inthisstudy,anewMVPAapproachbasedon sparserepresentationhasbeenemployedtoinvestigatetheanatomicalcovariancepatternsofnormalaging.Twogroupsof participants (group 1:290 participants; group 2:56 participants) were evaluated in this study. These two groups were scannedwithtwo1.5TMRImachines.Inthefirstgroup,weobtainedthediscriminativepatternsusingat-testfilterand sparserepresentationstep.Wewereabletodistinguishtheyoungfromoldcohortwithaveryhighaccuracyusingonlya fewvoxelsofthediscriminativepatterns(group1:98.4%;group2:96.4%).Theexperimentalresultsshowedthattheselected voxelsmaybecategorizedintotwocomponentsaccordingtothetwostepsintheproposedmethod.Thefirstcomponent focusesontheprecentralandpostcentralgyri,andthecaudatenucleus,whichplayanimportantroleinsensorimotortasks. Thestrongestvolumereductionwithagewasobservedintheseclusters.Thesecondcomponentismainlydistributedover the cerebellum, thalamus, and right inferior frontal gyrus. These regions are not only critical nodes of the sensorimotor circuitry butalsothecognitivecircuitryalthough theirvolumeshowsarelativeresilienceagainstaging.Consideringthe voxelsselection procedure, wesuggestthattheagingof thesensorimotor andcognitivebrain regions identified inthis studyhasacovaryingrelationshipwitheachother. Citation:SuL,WangL,ChenF,ShenH,LiB,etal.(2012)SparseRepresen