Spatial and Temporal Clustering of Dengue Virus Transmission in Thai Villages 英文参考文献.docVIP

Spatial and Temporal Clustering of Dengue Virus Transmission in Thai Villages 英文参考文献.doc

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Spatial and Temporal Clustering of Dengue Virus Transmission in Thai Villages 英文参考文献

o PL SMEDICINE SpatialandTemporalClusteringofDengue VirusTransmissioninThaiVillages Mammen P.Mammen Jr.1*,Chusak Pimgate1,Constantianus J.M.Koenraadt2,Alan L.Rothman3,Jared Aldstadt4, Ananda Nisalak1,Richard G.Jarman1,James W. Jones5,Anon Srikiatkhachorn3,Charity Ann Ypil-Butac1,Arthur Getis4, Suwich Thammapalo6,Amy C.Morrison2,Daniel H.Libraty3,Sharone Green3,Thomas W. Scott2 1DepartmentofVirology,ArmedForcesResearchInstituteofMedicalSciences(AFRIMS),Bangkok,Thailand,2DepartmentofEntomology,UniversityofCalifornia,Davis, California,UnitedStatesofAmerica,3CenterforInfectiousDiseaseandVaccineResearch,UniversityofMassachusettsMedicalSchool,Worcester,Massachusetts,United StatesofAmerica,4DepartmentofGeography,SanDiegoStateUniversity,SanDiego,California,UnitedStatesofAmerica,5DepartmentofEntomology,AFRIMS,Bangkok, Thailand,6OfficeofDiseasePreventionandControl,MinistryofPublicHealth,Nonthaburi,Thailand Funding:Thisstudywascofunded byU.S.NationalInstitutesofHealth (NIH)grantnumberP01AI34533,the U.S.MilitaryInfectiousDisease ResearchProgram,and19900funds fromtheStateofCalifornia.The fundershadnoroleinstudydesign, datacollectionandanalysis,decision topublish,orpreparationofthe manuscript.Theopinionsand assertionscontainedhereinarenot tobeconstruedasofficialoras reflectingtheviewsoftheU.S. government. ABSTRACT Background Transmissionofdengueviruses(DENV),theleadingcauseofarboviraldiseaseworldwide,is knowntovarythroughtimeandspace,likelyowingtoacombinationoffactorsrelatedtothe humanhost,virus,mosquitovector,andenvironment.Animprovedunderstandingofvariation intransmissionpatternsisfundamentaltoconductingsurveillanceandimplementingdisease preventionstrategies.TotestthehypothesisthatDENVtransmissionisspatiallyandtemporally focal,wecomparedgeographicandtemporalcharacteristicswithinThaivillageswhereDENV areandarenotbeingactivelytransmitted. CompetingInterests:Theauthors havedeclaredthatnocompeting interestsexist. MethodsandFindings AcademicEditor:StevenRiley, HongKongUniver

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