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Spatial and Temporal Clustering of Dengue Virus Transmission in Thai Villages 英文参考文献
o
PL SMEDICINE
SpatialandTemporalClusteringofDengue
VirusTransmissioninThaiVillages
Mammen P.Mammen Jr.1*,Chusak Pimgate1,Constantianus J.M.Koenraadt2,Alan L.Rothman3,Jared Aldstadt4,
Ananda Nisalak1,Richard G.Jarman1,James W. Jones5,Anon Srikiatkhachorn3,Charity Ann Ypil-Butac1,Arthur Getis4,
Suwich Thammapalo6,Amy C.Morrison2,Daniel H.Libraty3,Sharone Green3,Thomas W. Scott2
1DepartmentofVirology,ArmedForcesResearchInstituteofMedicalSciences(AFRIMS),Bangkok,Thailand,2DepartmentofEntomology,UniversityofCalifornia,Davis,
California,UnitedStatesofAmerica,3CenterforInfectiousDiseaseandVaccineResearch,UniversityofMassachusettsMedicalSchool,Worcester,Massachusetts,United
StatesofAmerica,4DepartmentofGeography,SanDiegoStateUniversity,SanDiego,California,UnitedStatesofAmerica,5DepartmentofEntomology,AFRIMS,Bangkok,
Thailand,6OfficeofDiseasePreventionandControl,MinistryofPublicHealth,Nonthaburi,Thailand
Funding:Thisstudywascofunded
byU.S.NationalInstitutesofHealth
(NIH)grantnumberP01AI34533,the
U.S.MilitaryInfectiousDisease
ResearchProgram,and19900funds
fromtheStateofCalifornia.The
fundershadnoroleinstudydesign,
datacollectionandanalysis,decision
topublish,orpreparationofthe
manuscript.Theopinionsand
assertionscontainedhereinarenot
tobeconstruedasofficialoras
reflectingtheviewsoftheU.S.
government.
ABSTRACT
Background
Transmissionofdengueviruses(DENV),theleadingcauseofarboviraldiseaseworldwide,is
knowntovarythroughtimeandspace,likelyowingtoacombinationoffactorsrelatedtothe
humanhost,virus,mosquitovector,andenvironment.Animprovedunderstandingofvariation
intransmissionpatternsisfundamentaltoconductingsurveillanceandimplementingdisease
preventionstrategies.TotestthehypothesisthatDENVtransmissionisspatiallyandtemporally
focal,wecomparedgeographicandtemporalcharacteristicswithinThaivillageswhereDENV
areandarenotbeingactivelytransmitted.
CompetingInterests:Theauthors
havedeclaredthatnocompeting
interestsexist.
MethodsandFindings
AcademicEditor:StevenRiley,
HongKongUniver
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