Spatiotemporal air pollution exposure assessment for a Canadian population-based lung cancer case-control study 英文参考文献.docVIP
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Spatiotemporal air pollution exposure assessment for a Canadian population-based lung cancer case-control study 英文参考文献
Hystadetal.EnvironmentalHealth2012,11:22
/content/11/1/22
RESEARCH
OpenAccess
Spatiotemporalairpollutionexposureassessment
foraCanadianpopulation-basedlungcancer
case-controlstudy
PerryHystad1*,PaulADemers2,KennethCJohnson3,JeffBrook4,AaronvanDonkelaar5,LokLamsal6,
RandallMartin7andMichaelBrauer8
Abstract
Background:Fewepidemiologicalstudiesofairpollutionhaveusedresidentialhistoriestodeveloplong-term
retrospectiveexposureestimatesformultipleambientairpollutantsandvehicleandindustrialemissions.We
presentsuchanexposureassessmentforaCanadianpopulation-basedlungcancercase-controlstudyof8353
individualsusingself-reportedresidentialhistoriesfrom1975to1994.Wealsoexaminetheimplicationsof
disregardingand/orimproperlyaccountingforresidentialmobilityinlong-termexposureassessments.
Methods:Nationalspatialsurfacesofambientairpollutionwerecompiledfromrecentsatellite-basedestimates
(forPM2.5 andNO2)andachemicaltransportmodel(forO3).Thesurfaceswereadjustedwithhistoricalannualair
pollutionmonitoringdata,usingeitherspatiotemporalinterpolationorlinearregression.Modelevaluationwas
conductedusinganindependenttenpercentsubsetofmonitoringdataperyear.Proximitytomajorroads,
incorporatingatemporalweightingfactorbasedonCanadianmobile-sourceemissionestimates,wasusedto
estimateexposuretovehicleemissions.Acomprehensiveinventoryofgeocodedindustrieswasusedtoestimate
proximitytomajorandminorindustrialemissions.
Results:CalibrationofthenationalPM2.5 surfaceusingannualspatiotemporalinterpolationpredictedhistorical
PM2.5 measurementdatabest(R2=0.51),whilelinearregressionincorporatingthenationalsurfaces,atime-trend
andpopulationdensitybestpredictedhistoricalconcentrationsofNO2(R2=0.38)andO3(R2=0.56).Applyingthe
modelstostudyparticipantsresidentialhistoriesbetween1975and1994resultedinmeanPM2.5,NO2andO3
3
exposuresof11.3μg/m (SD=2.6),17.7ppb(4.1),and26.4ppb(3.4)respectively.Onaverage,individualslived
within300mofahighwayfor2.9years(15%ofexposure-years)andwithin3kmofamajorindustrialemitterfor
6.4yea
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