Spatiotemporal regulation of the cough motor pattern 英文参考文献.docVIP

Cough BioMedCentral Research Open Access Spatiotemporal regulation of the cough motor pattern Cheng Wang1, Sourish Saha2, Melanie J Rose1, Paul W Davenport1 and Donald C Bolser*1 Address: 1Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida, 32610, USA and 2Department of Statistics, College of Liberal Arts and Sciences, University of Florida, Gainesville, Florida, 32611, USA Email: Cheng Wang - wangchengnju@; Sourish Saha - sourish.saha@; Melanie J Rose - rosem@; Paul W Davenport - davenportp@; Donald C Bolser* - bolserd@ * Corresponding author Published: 22 December 2009 Received: 3 March 2009 Accepted: 22 December 2009 Cough 2009, 5:12 doi:10.1186/1745-9974-5-12 This article is available from: /content/5/1/12 ? 2009 Wang et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract The purpose of this study was to identify the spatiotemporal determinants of the cough motor pattern. We speculated that the spatial and temporal characteristics of the cough motor pattern would be regulated separately. Electromyograms (EMG) of abdominal muscles (ABD, rectus abdominis or transversus abdominis), and parasternal muscles (PS) were recorded in anesthetized cats. Repetitive coughing was produced by mechanical stimulation of the lumen of the intrathoracic trachea. Cough inspiratory (CTI) and expiratory (CTE) durations were obtained from the PS EMG. The ABD EMG burst was confined to the early part of CTE and was followed by a quiescent period of varying duration. As such, CTE was divided into two segments with CTE1 defined as the duration of the ABD EMG burst and CTE2 defined as the period of little or no EMG activity in the ABD EMG. Total cough c