Thyroid transcription factor-1 positive primary breast cancer a case report with review of the literature 英文参考文献.docVIP

Klingen et al. Diagnostic Pathology 2010, 5:37 /content/5/1/37 CASE REPORT Open Access Thyroid transcription factor-1 positive primary Case Report breast cancer: a case report with review of the literature Tor A Klingen*1, Ying Chen1, Marian D Gundersen2, Hans Aas3, Bj?rn Westre4 and Torill Sauer5 Abstract This case describes an infiltrating breast tumour with thyroid transcription factor-1 (TTF-1) positive staining and ductal differentiation in a 72-year-old woman. The presence of ductal carcinoma in situ with positive TTF-1 is a strong indication that this is a primary tumour and not a metastasis from lung. On PET scan and CT follow up there were no other tumours found in this patient. We are not aware of any previously reported TTF-1 positive primary breast carcinoma with ductal differentiation. Background nant in appearance. The total maximal diameter includ- ing the calcifications was approximately 6 cm. TTF-1 is a tissue-specific transcription factor expressed in epithelial cells of the lung and the thyroid, including C- Ultrasound left breast showed an irregular solid malig- cells as well as certain areas of the brain. TTF-1 is nant appearing tumour, corresponding to the mammo- expressed in approximately 72% of pulmonary adenocar- cinomas[1], and may be a valuable marker for identifying the lung as the site of origin of a metastatic adenocarci- noma. graphic lesion, measuring approximately 38 mm maximal diameter. No enlarged lymph nodes in the left axillae. PET scan and CT scan showed no other malignancy other than known breast tumour. As no other origin for the tumour was found, the patient was treated with left mastectomy and sentinel lymph node mapping. The sentinel node was normal. The patient had an uncomplicated recovery and was dis- charged the next day following the operation. Case Presentation A 72-year-old gravida 1/para 1 woman presented with a palpable mass in the left br