Transfer Entropy Estimation and Directional Coupling Change Detection in Biomedical Time Series 英文参考文献.docVIP

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Transfer Entropy Estimation and Directional Coupling Change Detection in Biomedical Time Series 英文参考文献.doc

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Transfer Entropy Estimation and Directional Coupling Change Detection in Biomedical Time Series 英文参考文献

Leeetal.BioMedicalEngineeringOnLine2012,11:19 /content/11/1/19 RESEARCH OpenAccess TransferEntropyEstimationandDirectional CouplingChangeDetectioninBiomedical TimeSeries JoonLee1*,ShamimNemati2,3,IkaroSilva1,BradleyAEdwards3,JamesPButler3andAtulMalhotra3 *Correspondence:joonlee@mit. Abstract edu 1Harvard-MITDivisionofHealth SciencesandTechnology, Cambridge,MA,USA Background:Thedetectionofchangeinmagnitudeofdirectionalcoupling betweentwonon-lineartimeseriesisacommonsubjectofinterestinthe Fulllistofauthorinformationis availableattheendofthearticle biomedicaldomain,includingstudiesinvolvingtherespiratorychemoreflexsystem. Althoughtransferentropyisausefultoolinthisavenue,nostudytodatehas investigatedhowdifferenttransferentropyestimationmethodsperformintypical biomedicalapplicationsfeaturingsmallsamplesizeandpresenceofoutliers. Methods:Withrespecttodetectionofincreasedcouplingstrength,wecompared threetransferentropyestimationtechniquesusingbothsimulatedtimeseriesand respiratoryrecordingsfromlambs.Thefollowingestimationmethodswereanalyzed: fixed-binningwithranking,kerneldensityestimation(KDE),andtheDarbellay-Vajda (D-V)adaptivepartitioningalgorithmextendedtothreedimensions.Inthesimulated experiment,samplesizewasvariedfrom50to200,whilecouplingstrengthwas increased.Inordertointroduceoutliers,theheavy-tailedLaplacedistributionwas utilized.Inthelambexperiment,theobjectivewastodetectincreasedrespiratory- relatedchemosensitivitytoO2andCO2inducedbyadrug,domperidone.Specifically, theseparateinfluenceofend-tidalPO2andPCO2onminuteventilation(V˙E)before andafteradministrationofdomperidonewasanalyzed. Results:Inthesimulation,KDEdetectedincreasedcouplingstrengthatthelowest SNRamongthethreemethods.Inthelambexperiment,D-Vpartitioningresultedin thestatisticallystrongestincreaseintransferentropypost-domperidonefor PO →V˙ .Inaddition,D-Vpartitioningwastheonlymethodthatcoulddetectan increaseintransferentropyforPCO findings. V˙ ,inagreementwithexperimental → Conclusions:Transferentropyisc