Tregs combined with mature donor T cells hasten immune reconstitution without triggering GvHD in HLA haploidentical transplantation 英文参考文献.docVIP

ArthritisResearchTherapy2011,Volume13Suppl2 /supplements/13/S2 MEETING ABSTRACTS OpenAccess KitasatoSymposium2011:Translationalprospects forcytokinesin2011 Potsdam,Germany.22-23September2011 EditedbyGerdRBurmester,PeterELipskyandThomasD?rner Published:16September2011 Theseabstractsareavailableonlineat/supplements/13/S2 INTRODUCTION KEYNOTELECTUREPRESENTATION I1 K1 Kitasatosymposium2011:translationalprospectsforcytokines DissectingthehumanTandBcellresponsetopathogens AntonioLanzavecchia 1InstituteforResearchinBiomedicine,Bellinzona,Switzerland; 2Instituteof MicrobiologyETH-Zurich,Zurich,Switzerland ArthritisResearchTherapy2011,13(Suppl2):K1 GerdRBurmester1,PeterELipsky ,ThomasD?rner , 2 2* 1,2 theKitasatoMeetingFaculty 1Dept.Medicine/RheumatologyandClinicalImmunologyChariteUniversity Medicine,Berlin,Germany; 2Charlottesville,NC,USA ArthritisResearchTherapy2011,13(Suppl2):I1 Memory T and B lymphocytes and long lived plasma cells represent a repository ofthe antigenic experience ofanindividual. By analyzing the specificity and function of these cells we can gain insights into the human immune response and identify mechanisms of protection and immunopathology.Wehavedevelopedmethodstodissectthefunctional heterogeneity and antigenic repertoire of human T cells, B cells and plasma cells. These methods are used: i) to identify subsets of effector and memory T cells with distinct roles in immune surveillance and protection indifferent tissuesagainstdifferent classesofpathogens, and ii) to dissect the relative role of plasma cells and memory B cells in the antibody response to pathogens and to isolate broadly neutralizing antibodies. A better understanding of the class and specificity of the human immune response will be instrumental to guide the design of effectivevaccines. After successful meetings in 2009 and 2010, an international faculty of largely immunologists and rheumatologists will gather in Potsdam on nd rd September22 and23 ,2011todiscusstheimpactofc