Visfatin, glucose metabolism and vascular disease a review of evidence 英文参考文献.docVIP

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Visfatin, glucose metabolism and vascular disease a review of evidence 英文参考文献.doc

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Visfatin, glucose metabolism and vascular disease a review of evidence 英文参考文献

Saddi-Rosaetal.DiabetologyMetabolicSyndrome2010,2:21 /content/2/1/21 DIABETOLOGY METABOLIC SYNDROME REVIEW OpenAccess Visfatin,glucosemetabolismandvascular disease:areviewofevidence PedroSaddi-Rosa1,CarolinaSVOliveira1,FernandoMAGiuffrida1,2,AndréFReis1* Abstract Theadiposetissueisanendocrineorganproducingsubstancescalledadipocytokinesthathavedifferenteffectson lipidmetabolism,metabolicsyndrome,andcardiovascularrisk.Visfatinwasrecentlydescribedasanadipocytokine withpotentiallyimportanteffectsonglucosemetabolismandatherosclerosis.Visfatinhasbeenlinkedtoseveral inflammatoryconditions,betacellfunction,andcardiovasculardisease.Thegrowingnumberofpublicationsonthe subjectshallbringfurtherevidenceaboutthisadipocytokine.Itsfindingsmaycontributeintheidentificationof higherriskindividualsfordiabetesandcardiovasculardiseasewithabettercomprehensionaboutthecomplex intercorrelationbetweenadiposity,glucosemetabolismandvasculardisease. Introduction Atherosclerosis is a complex inflammatory disease, The ongoing global epidemic ofatherosclerotic disease involving many physiological mechanisms, in which is propelled by a concurrent rise in the prevalence of immunologic,metabolic,genetic,andenvironmentalfac- obesity,insulinresistance,andtype2diabetes(T2DM). tors interact. The endothelium plays a pivotal role in Inthissetting,thecoexistenceofseveralcardiovascular theseinteractions, throughdisequilibrium inregulation riskfactorsaggregatingaroundthemetabolicsyndrome of vascular tonus (endothelium-dependent relaxation), (MS),suchashyperglycemia,hypertension,dyslipidemia platelet aggregation, coagulation, and fibrinolysis [4]. andvisceralobesity,iswell-known[1].Thepathophysio- Risk factors for this condition have been continuously logical relationship between cardiovascular disease and these risk factors is of great importance due to their identified. Adipocytokines mayhave arole in each one of these high morbidity and mortality as well as impact on processes