Effect of the Glycemic Index of Carbohydrates on？Acne？vulgaris.docVIP

Nutrients 2010, 2, 1060-1072; doi:10.3390/nu2101060 OPEN ACCESS nutrients ISSN 2072-6643 /journal/nutrients Article Effect of the Glycemic Index of Carbohydrates on Acne vulgaris Rebecca C. Reynolds 1,*, Stephen Lee 2, James Y. J. Choi 2, Fiona S. Atkinson 1, Karola S. Stockmann 1, Peter Petocz 3 and Jennie C. Brand-Miller 1 1 Human Nutrition Unit, School of Molecular Bioscience G08, The University of Sydney, NSW 2006, Australia; E-Mails: fiona.atkinson@.au (F.S.A.); karola.stockmann@.au (K.S.S.); jennie.brandmiller@.au (J.C.B.M.) 2 Department of Dermatology, Concord Repatriation General Hospital, The University of Sydney, NSW 2006, Australia; E-Mails: stephen.lee@.au (S.L.); jameschoi@.au (J.Y.J.C.) 3 Department of Statistics, Macquarie University, NSW 2109, Australia; E-Mail: ppetocz@.au * Author to whom correspondence should be addressed; E-Mail: r.reynolds@.au. Received: 3 September 2010; in revised form: 12 October 2010 / Accepted: 15 October 2010 / Published: 18 October 2010 Abstract: Acne vulgaris may be improved by dietary factors that increase insulin sensitivity. We hypothesized that a low-glycemic index diet would improve facial acne severity and insulin sensitivity. Fifty-eight adolescent males (mean age ± standard deviation 16.5 ± 1.0 y and body mass index 23.1 ± 3.5 kg/m2) were alternately allocated to high or low glycemic index diets. Severity of inflammatory lesions on the face, insulin sensitivity (homeostasis modeling assessment of insulin resistance), androgens and insulin-like growth factor-1 and its binding proteins were assessed at baseline and at eight weeks, a period corresponding to the school term. Forty-three subjects (n = 23 low glycemic index and n = 20 high glycemic index) completed the study. Diets differed significantly in glycemic index (mean ± standard error of the mean, low glycemic index 51 ± 1 vs. high glycemic index 61 ± 2,