Effect of the Molecular Mass of Tremella Polysaccharides on Accelerated Recovery from Cyclophosphamide-Induced Leucopenia in Rats.docVIP

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Effect of the Molecular Mass of Tremella Polysaccharides on Accelerated Recovery from Cyclophosphamide-Induced Leucopenia in Rats.doc

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Effect of the Molecular Mass of Tremella Polysaccharides on Accelerated Recovery from Cyclophosphamide-Induced Leucopenia in Rats

Molecules 2012, 17, 3609-3617; doi:10.3390/moleculeOPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Effect of the Molecular Mass of Tremella Polysaccharides on Accelerated Recovery from Cyclophosphamide-Induced Leucopenia in Rats Rui-Zhi Jiang 1, Ying Wang 1, Hao-Ming Luo 2, Yan-Qiu Cheng 3, Ying-Hong Chen 1, Yang Gao 3 and Qi-Pin Gao 3,* 1 Jilin Academy of Chinese Medicine and Material Medica Science, Changchun 130012, Jilin, China; E-Mail: zhongyanjrz@ (R.-Z.J.) 2 College of Pharmacy, Jilin University, Changchun 130021, Jilin, China; E-Mail: Luo.haoming@163.com 3 Center for New Medicine Research, Changchun University of Chinese Medicine, Changchun 130021, Jilin, China * Author to whom correspondence should be addressed; E-Mail:gaoqipin@; Tel.: +86-431-8605-8660; Fax: +86-431-8605-8601. Received: 11 January 2012; in revised form: 3 March 2012 / Accepted: 12 March 2012 / Published: 23 March 2012 Abstract: The body of tremella were decocted with water, and hydrolyzed with 0.1 mol/L hydrochloric acid for different times, giving tremella polysaccharides with six molecular mass values. The structures of all the tremella polysaccharides had non-reducing terminals of β-D-pyranglucuronide, the backbone was composed of (1→3)-linked β-D-manno- pyranoside, and the side chain composed of (1→6)-linked β-D-xylopyranoside was attached to the C2 of the backbone mannopyranoside. Immunomodulatory effect studies indicated that tremella polysaccharides increased the counts of leukocytes in the peripheral blood which were significantly lowered by cyclophosphamide, and the lower the molecular mass of the tremella polysaccharide, the better this effect was. Keywords: tremella polysaccharide; hydrolysis; molecular mass; cyclophosphamide-induced leucopenia Molecules 2012, 17 3610 1. Introduction Cancer is one of the leading causes of death in the world. Chemotherapeutics are often used to inhibit the p