Effects of epinephrine and vasopressin on end-tidal carbon dioxide tension and mean arterial blood pressure in out-of-hospital cardiopulmonary resuscitation an observational study.docVIP

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Effects of epinephrine and vasopressin on end-tidal carbon dioxide tension and mean arterial blood pressure in out-of-hospital cardiopulmonary resuscitation an observational study.doc

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Available online /content/11/2/R39 Research Open Access Vol 11 No 2 Effects of epinephrine and vasopressin on end-tidal carbon dioxide tension and mean arterial blood pressure in out-of-hospital cardiopulmonary resuscitation: an observational study Stefan Mally, Alina Jelatancev and Stefek Grmec Centre for Emergency Medicine Maribor, Ljubljanska 5, 2000 Maribor, Slovenia Corresponding author: Stefan Mally, stefan.mally@ Received: 17 Oct 2006 Revisions requested: 22 Nov 2006 Revisions received: 28 Feb 2007 Accepted: 21 Mar 2007 Published: 21 Mar 2007 Critical Care 2007, 11:R39 (doi:10.1186/cc5726) This article is online at: /content/11/2/R39 ? 2007 Mally et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction Clinical data considering vasopressin as an at admission to the hospital (OR: 1.79) were associated with survival at 24 hours. Initial (OR: 1.61), average (OR: 1.47), and final (OR: 2.67) end-tidal carbon dioxide values as well as MAP (OR: 1.39) were associated with improved hospital discharge. In the vasopressin group, significantly more pulse restorations and a better rate of survival at 24 hours were observed (p 0.05). Subgroup analysis of patients with initial asystole revealed a higher hospital discharge rate when vasopressin was used (p = 0.04). Neurological outcome in discharged patients was better in the vasopressin group (p = 0.04). equivalent option to epinephrine in cardiopulmonary resuscitation (CPR) are limited. The aim of this prehospital study was to assess whether the use of vasopressin during CPR contributes to higher end-tidal carbon dioxide and mean arterial blood pressure (MAP) levels and thus improves the survival rate and neurological outco