Effects of ethnicity and vitamin D supplementation on vitamin D status and changes in bone mineral content in infants.docVIP

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Effects of ethnicity and vitamin D supplementation on vitamin D status and changes in bone mineral content in infants.doc

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Effects of ethnicity and vitamin D supplementation on vitamin D status and changes in bone mineral content in infants

Abramsetal.BMCPediatrics2012,12:6 /1471-2431/12/6 RESEARCH ARTICLE OpenAccess EffectsofethnicityandvitaminD supplementationonvitaminDstatusand changesinbonemineralcontentininfants StevenAAbrams1*,KeliMHawthorne1,StefaniePRogers1,PenniDHicks1andThomasOCarpenter2 Abstract Background:Toevaluatetheeffectsonserum25(OH)Dandbonemineralizationofsupplementationofbreast-fed Hispanicandnon-HispanicCaucasianinfantswithvitaminDininfantsinHouston,Texas. Methods:Wemeasuredcordserum25(OH)Dlevels,bonemineralcontent(BMC),bonemineraldensity(BMD)and theirchangesover3monthsoflifewith400IU/dayofvitaminD3supplementation. Results:Cordserum25(OH)DwassignificantlylowerinHispanicthannon-HispanicCaucasianinfants(16.4±6.5 ng/mL,n=27,vs22.3±9.4n=22,p=0.013).Among38infantswhocompleteda3monthvitaminD supplementationintervention,provisionof400IU/dayofvitaminDincreasedfinal25(OH)Dtoahigherlevelin non-HispanicCaucasiancomparedtoHispanicinfants.Therewasnosignificantrelationshipbetweencordserum 25(OH)DandBMCorBMDinthefirstweekoflife(n=49)orafter3monthsofvitaminDsupplementation. Conclusion:Lowcord25(OH)DlevelsareseeninHispanicinfants,buttheirfunctionalsignificanceisuncertain relatedtobonehealthinasouthernUSsetting.DailyvitaminDintakeof400IUduringthefirstmonthsoflife appearsadequatetoincreaseserum25(OH)DandsupportBMCincreasesdespitelowinitial25(OH)Dlevelsin someinfants.TrialRegistration ClincalTNCKeywords:breastfeeding,vitaminD,bonemineralcontent Background typicallyconsume300-500IU/dayfromtheirformulaand VitaminDhasbeengiventoinfantstopreventandtreat therefore generally meetthecurrent recommendations ricketsforalmost100years.Therecommendeddoseof withoutanadditionaloralsupplementofvitaminDdrops 400IU(10micrograms)dailyforinfantswasestablished especiallyafterthefirst6to8weeksoflife.Therelatively basedontypicalamountsinateaspoonofcodliveroil[1]. greater calcium and phosphorus concentration in US This recommendation has recently been reaffirmed as infantformulascomparedto