Evidence for a second class of S-adenosylmethionine riboswitches and other regulatory RNA motifs in alpha-proteobacteria.docVIP

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Evidence for a second class of S-adenosylmethionine riboswitches and other regulatory RNA motifs in alpha-proteobacteria.doc

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Evidence for a second class of S-adenosylmethionine riboswitches and other regulatory RNA motifs in alpha-proteobacteria

Open Access rch 2005CorbinoetVReal.lumesea6, Issue 8, Article R70 Evidence for a second class of S-adenosylmethionine riboswitches and other regulatory RNA motifs in alpha-proteobacteria Keith A Corbino*, Jeffrey E Barrick?, Jinsoo Lim*, Rüdiger Welz*?, Brian J Tucker?, Izabela Puskarz*, Maumita Mandal*§, Noam D Rudnick* and Ronald R Breaker* Addresses: *Department of Molecular, Cellular and Developmental Biology, Yale University, P.O. Box 208103, New Haven, CT 06520-8103, USA. ?Department of Molecular Biophysics and Biochemistry, Yale University, P.O. Box 208103, New Haven, CT 06520-8103, USA. ?Department of Chemistry, Yale University, P.O. Box 208103, New Haven, CT 06520-8103, USA. §Department of Physics, University of California, Berkeley, CA 94720-7200, USA. Correspondence: Ronald R Breaker. E-mail: ronald.breaker@ Published: 1 August 2005 Received: 28 April 2005 Revised: 15 June 2005 Accepted: 1 July 2005 Genome Biology 2005, 6:R70 (doi:10.1186/gb-2005-6-8-r70) The electronic version of this article is the complete one and can be found online at /2005/6/8/R70 ? 2005 Corbino et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. SAM-IItuhpmateCifsoanmcriboswitchesioeptnafsroautn/ividteisnanGqduandraeonmthc-otherepraoαnsi-atpliRNAyvrsoeitsbeoamotifscnbtadecrsttearr.uiinac/.tpubacteriaOralneprobingof these identifiedRNA el mfiveentsRNAis proelementsbably a SinAMthe-IIintergenic, the only rregioniboswitofchitAgrobacteriumclass identifi d so far Abstract Background: Riboswitches are RNA elements in the 5 untranslated leaders of bacterial mRNAs that directly sense the levels of specific metabolites with a structurally conserved aptamer domain to regulate expression of downstream genes. Riboswitches are most common i