第5章-1蛋白分选与膜泡运输11li1.pptVIP

A reaction catalyzed by a glycosyltransferase 供体 UDP-N-acetyglucosamine UDP-N-acetyglucosamine 受体 E Quality Control Glucosyltransferase (GT) Quality control （质量控制) of newly synthesized proteinsThe role of N-linked glycosylation（N-连接的糖基化） in ER protein folding Quality control: ensuring that misfolded proteins do not leave ER The lumen of RER contains: GT(glucosyltransferase) recognize unfolded or misfolded proteins and adds a glucose to the end of the oligo saccharide chains. BiP(结合蛋白) and calnexin（钙联接蛋白）or calreticulin(钙网蛋白) (chaperones) : that recognize and bind to unfolded or misfolded