股骨头坏死病因与发病机制研究进展.docVIP

股骨头坏死病因与发病机制研究进展 股骨头坏死各学说之间相互作用、相互促进，各种危险因素最终可能通过一共同的途径——血管内凝血导致股骨头缺血坏死。虽然国内外学者在股骨头坏死的病因和发病机制方面做了大量工作，但在基础研究和临床 治疗 方面并没有取得突破性的进展，股骨头坏死的病因和发病机制仍未完全阐明，部分原因可能是股骨头坏死动物模型与人类股骨头坏死的发病机制和病理过程还有一定的差别，所以还需进一步探索可用于评估各种病因的动物模型的建立，以对股骨头缺血坏死的病因和发病机制有更深入的了解。论文联盟www.LWLM.com编辑。 【 参考 文献 】 ［1］ Ficat RP.Idiopathic bone necrosis of the femoral head.Early diagnosis and treatment［J］.J Bone Joint Surg（Br）,1985,3-9. ［2］ Wai Man Tang,KYC.Avascular necrosis of femoral head: a short review［J］.2006,98-101. ［3］ Jones,JP,Jr.Fat embolism and osteonecrosis［J］.Orthop Clin North Am,1985,16:595-633. ［4］ Lee JS,Lee JS, Rob HL, et al.Alterations in the differentiation ability of mesenchymal stem cells in patients with nontraumatic osteonecrosis of the femoral head: comparative analysis according to the risk factor［J］.J Orthop Res,2006,24:604-609. ［5］ Mont MA,Jones LC,Hungerford DS.Nontraumatic osteonecrosis of the femoral head:ten years later［J］.J Bone Joint Surg（Am）,2006,88:1117-1132. ［6］ Inoue S,Horii M,Asano T, et al.Risk factors for nontraumatic osteonecrosis of thefemoral head after renal transplantation［J］.J Orthop Sci,2003,8:751-756. ［7］ Griffith JF,Antonio GE,Kumta SM,et al.Osteonecrosis of hip and knee in patientswith severe acute respiratory syndrome treated with steroids［J］.Radiology,2005,235:168-175. ［8］ Parsons SJ, Steele N. Osteonecrosis of the femoral head: Part 1Aetiology,pathogenesis,investigation,classification［J］.Current Orthopaedics,2007,21:457-463. ［9］ Kubo T, Fujioka M, Yamazoe S, et al. Relationship between steroid dosage andosteonecrosis of the femoral head after renal transplantation as measured by magnetic resonancEimaging［J］.Transplant Proc,1998,30:3039-3040. ［10］Glueck CJ,FrEIberg RA,Sieve L,et al.Enoxaparin prevents progression of stages and Ⅱ osteonecrosis of the hip［J］ Clin Orthop Relat Res,2005,164-170. ［11］Kang P,Shen B,Yang J,et al.Circulating plateletderived microparticles and endotheliumderived microparticles may be a potential cause of microthrombosis in pa