1例自身抗体致主侧配血不合G6PD缺乏症严重贫血患儿疗效观察.pdfVIP

• 215 • 临床输血与检验 2016年6 月第 18 卷第3 期 1 例自身抗体致主侧配血不合G6PD缺乏症严重贫血患儿 疗效观察 陈志忠李结敏余文潮谭晓颖陈尚良赵嘉庆 【摘要】 目的为l 例自身抗体阳性的葡萄糖-6-磷酸脱氢酶缺乏症(G6PD)贫血患儿筛选合适红细胞血液制剂，纠正其 低血红蛋白血症。方法采用微柱凝胶法进行血型鉴定，抗人球蛋白法进行抗体筛查和交叉配血。结果患儿存在自身抗体 干扰交叉配血主侧试验，经盲配多个供者，为患儿选择了2单位主侧凝集强度小于或者接近自身对照的红细胞进行临床 输注。结论自身抗体致主侧配血不合非临床输血的绝对禁忌，输注1.5 U红细胞悬浮液后，患儿血红蛋白得到有效提升。 【关键词】 自身抗体 同种抗体 输血疗效 【申图分类号】 R457.1 【文献标识码】 A [文章编号】 1671-2587(2016)03-0215-03 Therapeutic Effect of Blood Transfusion in One Anemia Patient with G6PD Deficiency Caused by Autoantibody CHEN Zhi-zhong, LI Jie-ming, YU Wen-chao, et al. Zhaoqing Blood Center of Guangdong Province 526020 Abstract Objective To select matching red blood cells and promote hemoglobin level for anemia patient with autoantibody caused by G6PD deficiency. Methods Blood group typing , antibody screening and cross matching were tested by micro column gel method. Results Autoantibody was identified in the patient , which caused interference with main side in cross-match. Two units of RBC , whose main side agglutination intensity was lower than or similar to self-control , were selected after cross-matching multiple donors , and transfused to the patien t. Conclusions Main side agglutination due to autoantibody is not an absolute contraindication for transfusion , and the hemoglobin of patient is effectively improved after transfusion of 1.5 U RBC. Key words Autoantibody Iso-antibody Transfusion efficacy 含自身抗体的患者，其血清学检测比较复 1 临床资料患儿巫XX，男，年龄8个月，无输血 杂，给交叉配血带来很大的困扰。自身抗体未必 史， 0型Rh D阳性，母亲0型Rh D阳性。 G6PD 缺 会引起急性输血反应，同种抗体的存在却可能给 乏症溶血性贫血待输血，与数名O型供血者交叉配 输血带来致命的风险:前者可能掩盖后者的存