肾小管上皮_间充质转化的研究现状_李旭艳.pdfVIP

98 2013 4 2 2 Chin J Kidney Dis Invest (Electronic Edition), April 2013, Vol.2, No.2 - TIFESRD - EMTTIF EMT EMT EMT TIF - Research status of tubular epithelial-mesenchymal transition LI Xu-yan, XIE Yuan-sheng, CHEN Xiang-mei. Department of Nephrology, Kidney Institute of Chinese People’s Liberation Army, State Key Laboratory of Kidney Disease, Chinese People’s Liberation Army General Hospital, Beijing 100853, China Corresponding author: XIE Yuan-sheng, Email: xieyuansn@ AbstractRenal tubular interstitial fi brosis (TIF) is the fi nal common pathway of a wide variety of chronic kidney diseases that eventually lead to end-stage renal disease (ESRD). Growing evidence has implicated tubular epithelial-mesenchymal transition (EMT) as a major pathway leading to TIF in diseased kidneys. Therefore, EMT has become the focus of research in kidney diseases. The purpose of this study is to review the status of renal tubular EMT. It also summarizes the remaining problems and prospects for future research to provide new clues for the study of tubular EMT as well as the treatment of TIF. Key wordsRenal tubule;Epithelial-mesenchymal transition;Renal tubular interstitial fi brosis - e p i t h e l i a l - m e s e n c h y m a l α transition, EMT - [1-2] 13 EMT tubular interstitial [1-3,5] EMT fibrosisTIF [3] [1-2] EMT [4] 2. EMT EMT EMT TIF 3 [6-7] 1EMT EMT EMT EMT TIF TIF 2 EMT EMT